HitPredict

Interactor 1: MED7 (O43513)
Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)
Gene: MED7

Interactor 2: MED8 (Q96G25)
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
Gene: MED8

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.932

The method score is based on:

Property Details
Experiments 26186194, 28514442, 24981860, 33961781, 35271311
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Med7~Med8
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
and 6 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 233
Hs

1 268
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024