HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	35271311, 28514442, 27705803, 33601056, 33472061
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 488
+	Hs
		903202 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177249 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		209431 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1270423 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		245623 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038686 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		245600 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1270358 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270370 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		177377 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		177148 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Dm
		1182201 EBI_DROME (6-202): 3.98e-57: 198: 27.75		Q7KTS4_DROME (10-430): 0: 560: 57.11
+	Dm
		1279322 EBI_DROME (6-202): 3.98e-57: 198: 27.75		Q9VNC2_DROME (10-430): 0: 556: 56.88
+	Mm
		1112825 SMU1_MOUSE (30-331): 7.66e-39: 145: 28.71		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Hs
		1260185 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37
+	Hs
		245622 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37
+	Hs
		1260173 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37