HitPredict

Interactor 1: FOXS1 (O43638)
Forkhead box protein S1 (Forkhead-like 18 protein) (Forkhead-related transcription factor 10) (FREAC-10)
Gene: FOXS1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25609649
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0043433 - negative regulation of DNA-binding transcription factor activity GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 488
+	Hs
		964220 FOXK2_HUMAN (2-324): 2.45e-54: 190: 22.42		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		952845 FOXK1_HUMAN (2-316): 9e-52: 183: 25.31		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		877628 FOXG1_HUMAN (16-302): 2.94e-52: 181: 30.00		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270410 FOXC2_HUMAN (11-287): 3.91e-49: 173: 35.58		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		877999 FOXA3_HUMAN (5-128): 1.52e-47: 165: 50.81		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1021331 FOXL1_HUMAN (10-185): 3.38e-47: 164: 46.02		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		964178 FOXK2_HUMAN (2-324): 2.45e-54: 190: 22.42		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		952807 FOXK1_HUMAN (2-316): 9e-52: 183: 25.31		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038595 FOXJ1_HUMAN (1-272): 4.49e-53: 181: 28.83		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177261 FOXK2_HUMAN (2-324): 2.45e-54: 190: 22.42		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Sp
		223482 FKH2_SCHPO (8-269): 6.7e-50: 177: 22.06		CLR6_SCHPO (6-406): 0: 563: 60.89
+	Hs
		177281 FOXL1_HUMAN (10-185): 3.38e-47: 164: 46.02		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		1021370 FOXL1_HUMAN (10-185): 3.38e-47: 164: 46.02		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04
+	Hs
		877811 FOXA1_HUMAN (5-312): 1.66e-62: 207: 28.25		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37