Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2
Interactor 2: CD3E (P07766)
T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
Gene: CD3E
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.79 | 0.60 | 0.691 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32296183, 12110186, unassigned1304, 17617578 |
| Identification Methods | two hybrid, pull down, two hybrid array, validated two hybrid, two hybrid prey pooling approach, filamentous phage display |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005783 - endoplasmic reticulum GO:0007172 - signal complex assembly GO:0030159 - signaling receptor complex adaptor activity GO:0042102 - positive regulation of T cell proliferation GO:0042110 - T cell activation |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
