Protein: FADS1
Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1)

Gene: FADS1
Organism: Homo sapiens
Interactions: 102
UniProt ID: O60427

Gene Ontology (top 5):
GO:0000248 - C-5 sterol desaturase activity
GO:0005739 - mitochondrion
GO:0005789 - endoplasmic reticulum membrane
GO:0006355 - regulation of DNA-templated transcription
GO:0006629 - lipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

248602

SIR2
NAD-dependent protein deacetylase sirtuin-2

3

0

High-throughput

0.638

High

248576

VMAT1
Chromaffin granule amine transporter

2

8

High-throughput

0.628

High

248565

CD80
T-lymphocyte activation antigen CD80

1

2

High-throughput

0.618

High

248594

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.602

High

248632

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

2

0

High-throughput

0.602

High

182427

GP182
G-protein coupled receptor 182

2

11

High-throughput

0.601

High

248558

FPR1
fMet-Leu-Phe receptor

2

9

High-throughput

0.601

High

248557

KCNA2
Potassium voltage-gated channel subfamily A member 2

2

0

High-throughput

0.576

High

248612

BSCL2
Seipin

2

0

High-throughput

0.576

High

248560

NK1R
Substance-P receptor

2

4

High-throughput

0.574

High

248562

5HT2C
5-hydroxytryptamine receptor 2C

2

1

High-throughput

0.574

High

248564

GRPR
Gastrin-releasing peptide receptor

2

4

High-throughput

0.574

High

248590

S39AC
Zinc transporter ZIP12

2

3

High-throughput

0.574

High

248616

GPR21
Probable G-protein coupled receptor 21

2

1

High-throughput

0.574

High

248583

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

2

High-throughput

0.558

High

248578

CXCR4
C-X-C chemokine receptor type 4

2

10

High-throughput

0.549

High

183893

S22A2
Solute carrier family 22 member 2

1

4

High-throughput

0.536

High

248550

TSN15
Tetraspanin-15

1

4

High-throughput

0.536

High

248552

CD63
CD63 antigen

1

4

High-throughput

0.536

High

248563

V2R
Vasopressin V2 receptor

1

2

High-throughput

0.536

High

248568

GLR
Glucagon receptor

1

2

High-throughput

0.536

High

248574

PSN1
Presenilin-1

1

1

High-throughput

0.536

High

248588

PTHD3
Patched domain-containing protein 3

1

3

High-throughput

0.536

High

248605

ABCA6
ATP-binding cassette sub-family A member 6

1

1

High-throughput

0.536

High

248617

CML1
Chemerin-like receptor 1

1

7

High-throughput

0.536

High

248622

S22A4
Solute carrier family 22 member 4

1

4

High-throughput

0.536

High

248629

AT133
Polyamine-transporting ATPase 13A3

1

4

High-throughput

0.536

High

248638

SC5A6
Sodium-dependent multivitamin transporter

1

1

High-throughput

0.536

High

248572

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.515

High

248636

DHCR7
7-dehydrocholesterol reductase

1

1

High-throughput

0.515

High

248613

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

248614

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

248620

ASPC1
Tether containing UBX domain for GLUT4

1

0

High-throughput

0.513

High

248625

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

248635

TM63C
Osmosensitive cation channel TMEM63C

1

0

High-throughput

0.513

High

248639

B3GT5
Beta-1,3-galactosyltransferase 5

1

0

High-throughput

0.513

High

248640

BACE2
Beta-secretase 2

1

0

High-throughput

0.513

High

221443

OX2R
Orexin receptor type 2

1

2

High-throughput

0.489

High

248566

OPRX
Nociceptin receptor

1

3

High-throughput

0.489

High

248585

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

8

High-throughput

0.489

High

248596

VSTM1
V-set and transmembrane domain-containing protein 1

1

1

High-throughput

0.489

High

248598

SV2A
Synaptic vesicle glycoprotein 2A

1

3

High-throughput

0.489

High

248609

NPL4
Nuclear protein localization protein 4 homolog

1

1

High-throughput

0.489

High

248633

SC5A4
Probable glucose sensor protein SLC5A4

1

1

High-throughput

0.489

High

240220

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

248553

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

248556

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

248577

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.479

High

248579

RHOA
Transforming protein RhoA

1

11

High-throughput

0.479

High

248587

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.479

High

248600

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.479

High

248618

PAAF1
Proteasomal ATPase-associated factor 1

1

1

High-throughput

0.470

High

248604

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.460

High

248580

H4
Histone H4

1

0

High-throughput

0.458

High

248595

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

248601

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

248621

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

248623

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.458

High

248545

S19A2
Thiamine transporter 1

1

4

High-throughput

0.445

High

248555

FGFR1
Fibroblast growth factor receptor 1

1

1

High-throughput

0.445

High

248561

ACKR3
Atypical chemokine receptor 3

1

10

High-throughput

0.445

High

248567

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

2

High-throughput

0.445

High

248570

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.445

High

248571

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

3

High-throughput

0.445

High

248584

TRDN
Triadin

1

1

High-throughput

0.445

High

248586

S39AE
Metal cation symporter ZIP14

1

3

High-throughput

0.445

High

248592

GP107
Protein GPR107

1

2

High-throughput

0.445

High

248610

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

1

High-throughput

0.445

High

126387

RHOD
Rho-related GTP-binding protein RhoD

1

13

High-throughput

0.437

High

248551

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

248575

RND2
Rho-related GTP-binding protein RhoN

1

12

High-throughput

0.437

High

248581

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

248597

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

248599

RHOU
Rho-related GTP-binding protein RhoU

1

15

High-throughput

0.437

High

248615

RHOV
Rho-related GTP-binding protein RhoV

1

14

High-throughput

0.437

High

248619

RHBT2
Rho-related BTB domain-containing protein 2

1

11

High-throughput

0.437

High

248626

RHOJ
Rho-related GTP-binding protein RhoJ

1

11

High-throughput

0.437

High

248627

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

248630

RHOF
Rho-related GTP-binding protein RhoF

1

12

High-throughput

0.437

High

212523

GPAA1
GPI-anchor transamidase component GPAA1

1

0

High-throughput

0.426

High

248549

TNF13
Tumor necrosis factor ligand superfamily member 13

1

0

High-throughput

0.426

High

248569

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

High-throughput

0.426

High

248548

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.407

High

248573

CXCR3
C-X-C chemokine receptor type 3

1

8

High-throughput

0.407

High

248591

S35F1
Solute carrier family 35 member F1

1

1

High-throughput

0.407

High

248611

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.407

High

248582

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

3

0

High-throughput

0.347

High

248607

I17RC
Interleukin-17 receptor C

2

0

High-throughput

0.328

High

248634

RN181
E3 ubiquitin-protein ligase RNF181

2

0

High-throughput

0.328

High

248546

CCD22
Coiled-coil domain-containing protein 22

1

0

High-throughput

0.279

Low

248547

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.279

Low

248589

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

248606

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

248608

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

248631

NCKX3
Sodium/potassium/calcium exchanger 3

1

0

High-throughput

0.279

Low

248637

LAT2
Large neutral amino acids transporter small subunit 2

1

0

High-throughput

0.279

Low

248559

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.249

Low

248603

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

248624

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

248554

PIM1
Serine/threonine-protein kinase pim-1

1

0

High-throughput

0.232

Low

248593

TMM88
Transmembrane protein 88

1

0

High-throughput

0.232

Low

248628

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025