HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: WBP11 (Q9Y2W2)
WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)
Gene: WBP11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	16189514
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 641
+	Hs
		412418 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		WBP11_HUMAN (1-641): 2.71e-82: 273: 100.00
+	Hs
		209112 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		MINK1_HUMAN (381-554): 4.7e-10: 64.9: 23.56
+	Hs
		1078936 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		WBP11_HUMAN (1-641): 2.71e-82: 273: 100.00
+	Hs
		924973 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		WBP11_HUMAN (1-641): 2.71e-82: 273: 100.00
+	Hs
		203208 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		SYNJ1_HUMAN (279-640): 1.85e-13: 76: 10.43
+	Ce
		712432 Q95PW9_CAEEL (1-379): 5.2e-75: 239: 37.88		SC161_CAEEL (282-626): 1.57e-24: 111: 17.77
+	Hs
		557740 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		MINK1_HUMAN (381-554): 4.7e-10: 64.9: 23.56
+	Hs
		411582 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		MUC1_HUMAN (130-564): 8.42e-23: 106: 12.19
+	Hs
		554292 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MUC1_HUMAN (130-564): 8.42e-23: 106: 12.19
+	Hs
		522749 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		MUC1_HUMAN (130-564): 8.42e-23: 106: 12.19
+	Hs
		257713 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		ANR17_HUMAN (125-603): 3.77e-10: 65.6: 12.66
+	Hs
		203228 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		SYNJ1_HUMAN (279-640): 1.85e-13: 76: 10.43
+	Hs
		203198 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		SYNJ1_HUMAN (279-640): 1.85e-13: 76: 10.43
+	Hs
		203218 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		SYNJ1_HUMAN (279-640): 1.85e-13: 76: 10.43
+	Hs
		203230 SH319_HUMAN (1-57): 2.18e-16: 82.8: 19.30		SYNJ1_HUMAN (279-640): 1.85e-13: 76: 10.43
+	Hs
		203241 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		SYNJ1_HUMAN (279-640): 1.85e-13: 76: 10.43
+	Hs
		411790 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		MINK1_HUMAN (381-554): 4.7e-10: 64.9: 23.56
+	Hs
		924703 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MINK1_HUMAN (381-554): 4.7e-10: 64.9: 23.56
+	Hs
		924760 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PRG4_HUMAN (302-636): 7.23e-09: 61.3: 13.73