HitPredict

Interactor 1: RGS10 (O43665)
Regulator of G-protein signaling 10 (RGS10)
Gene: RGS10

Interactor 2: GNAZ (P19086)
Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha)
Gene: GNAZ

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8774883
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 355
+	Hs
		391357 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNAI2_HUMAN (1-354): 2.1e-177: 497: 66.38
+	Hs
		444692 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNAI3_HUMAN (1-354): 5.24e-174: 489: 67.23
+	Hs
		207505 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI2_HUMAN (1-354): 2.1e-177: 497: 66.38
+	Hs
		283156 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAI2_HUMAN (1-354): 2.1e-177: 497: 66.38
+	Hs
		207517 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI1_HUMAN (1-354): 9.58e-177: 495: 67.23
+	Hs
		277782 RGS9_HUMAN (2-172): 1.77e-56: 189: 30.90		GNAO_HUMAN (1-354): 2.98e-175: 492: 60.45
+	Hs
		283183 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAI1_HUMAN (1-354): 9.58e-177: 495: 67.23
+	Hs
		283160 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAO_HUMAN (1-354): 2.98e-175: 492: 60.45
+	Hs
		207507 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI3_HUMAN (1-354): 5.24e-174: 489: 67.23
+	Hs
		444693 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAI3_HUMAN (1-354): 5.24e-174: 489: 67.23
+	Mm
		579646 RGS14_MOUSE (21-175): 1.23e-55: 185: 45.22		GNAO_MOUSE (1-354): 5.63e-173: 486: 59.61
+	Hs
		670435 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNA11_HUMAN (1-354): 4.25e-164: 464: 46.76
+	Hs
		580410 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAZ_HUMAN (1-355): 4.02e-168: 474: 100.00
+	Hs
		170629 AXIN1_HUMAN (7-172): 6.4e-55: 187: 30.86		GNAS2_HUMAN (1-354): 2.36e-167: 473: 37.22
+	Hs
		283162 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAZ_HUMAN (1-355): 4.02e-168: 474: 100.00
+	Hs
		834946 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAQ_HUMAN (1-354): 1.59e-167: 472: 47.89
+	Dm
		558483 RGS_DROME (9-166): 4.56e-55: 189: 39.62		GNAO_DROME (1-354): 4.57e-166: 468: 61.02
+	Dm
		592744 RGS_DROME (9-166): 4.56e-55: 189: 39.62		GNAI_DROME (1-354): 5.46e-164: 463: 61.69
+	Hs
		207511 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNA11_HUMAN (1-354): 4.25e-164: 464: 46.76
+	Bt
		221230 RGS9_BOVIN (2-172): 4.58e-57: 187: 30.34		GNAT1_BOVIN (1-354): 2.49e-163: 462: 54.24