HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 731
+	Hs
		1049275 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		214131 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		LIS1_HUMAN (509-730): 2.11e-55: 197: 21.24
+	Hs
		196915 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59
+	Hs
		214231 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49
+	Hs
		1049215 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34
+	Hs
		1049297 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67