HitPredict

Interactor 1: MYO1B (O43795)
Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa)
Gene: MYO1B

Interactor 2: NEXN (Q0ZGT2)
Nexilin (F-actin-binding protein) (Nelin)
Gene: NEXN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0015629 - actin cytoskeleton GO:0051015 - actin filament binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1136 Hs			1 675
+	Hs
		214497 MYO1B_HUMAN (1-1136): 0: 1188: 100.00		VGFR1_HUMAN (527-673): 2.36e-31: 133: 22.73
+	Hs
		1077872 MYO5A_HUMAN (2-1125): 0: 1013: 28.64		MYLK_HUMAN (202-671): 7.89e-19: 93.8: 11.91
+	Mm
		250933 MYH6_MOUSE (1-1112): 0: 1033: 27.00		MYPC3_MOUSE (238-674): 4.61e-12: 71.8: 11.09
+	Hs
		297340 MYO1D_HUMAN (16-794): 0: 706: 47.73		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Ce
		136791 HUM6_CAEEL (16-808): 0: 963: 35.26		UNC89_CAEEL (106-595): 3.45e-10: 66.1: 7.78
+	Hs
		117678 MYO1C_HUMAN (778-1136): 9.49e-71: 259: 25.95		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Hs
		724795 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Hs
		117778 MYO1C_HUMAN (778-1136): 9.49e-71: 259: 25.95		PALLD_HUMAN (573-675): 5.3e-11: 68.3: 23.08
+	Hs
		522597 MYH7_HUMAN (735-1115): 6.56e-12: 72.3: 6.76		MYOM2_HUMAN (104-671): 9.09e-57: 211: 14.14
+	Hs
		522615 MYH7_HUMAN (735-1115): 6.56e-12: 72.3: 6.76		MYPC3_HUMAN (10-653): 5.58e-32: 135: 11.78
+	Hs
		724846 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		MYLK_HUMAN (202-671): 7.89e-19: 93.8: 11.91
+	Hs
		724937 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		PALLD_HUMAN (573-675): 5.3e-11: 68.3: 23.08