Interactor 1: ORC5 (O43913)
Origin recognition complex subunit 5
Gene: ORC5

Interactor 2: ORC3 (Q9UBD5)
Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo)
Gene: ORC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.945

The method score is based on:

Property Details
Experiments 12614612, 11395502, 11323433, 10402192, 15232106, 17716973
Identification Methods two hybrid, biochemical, pull down, affinity chromatography technology, anti bait coimmunoprecipitation, protein array
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA_16~ORC3_N, ORC3_N~ORC5_C, ORC5_C~ORC_WH_C
Common GO terms GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0000808 - origin recognition complex
GO:0003688 - DNA replication origin binding
GO:0005634 - nucleus
and 5 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 435
Hs

1 711
+ Hs
+ Hs
+ Dm
+ Hs
+ Dm
+ Dm
+ At
+ At
+ Sp
+ Sp
+ Dm
+ Sp
+ At
+ Sc
+ Sc
+ Sp
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024