Protein: ALDR
Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR)

Gene: ALDR, AKR1B1
Organism: Homo sapiens
Interactions: 57
UniProt ID: P15121

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001758 - retinal dehydrogenase (NAD+) activity
GO:0002070 - epithelial cell maturation
GO:0003091 - renal water homeostasis
GO:0004032 - aldose reductase (NADPH) activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

91829

AK1BF
Aldo-keto reductase family 1 member B15

3

12

High-throughput

0.848

High

572705

AK1A1
Aldo-keto reductase family 1 member A1

1

13

High-throughput

0.691

High

580389

TERA
Transitional endoplasmic reticulum ATPase

2

9

High-throughput

0.584

High

580414

EFC11
EF-hand calcium-binding domain-containing protein 11

2

3

High-throughput

0.553

High

580400

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.547

High

187278

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

3

High-throughput

0.536

High

580396

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.536

High

580381

TFE3
Transcription factor E3

1

1

High-throughput

0.515

High

580399

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

1

High-throughput

0.515

High

385416

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

580417

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

580386

APJ
Apelin receptor

1

3

High-throughput

0.494

High

580398

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.486

High

580391

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

142814

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

259378

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

580378

DESP
Desmoplakin

1

1

High-throughput

0.479

High

580379

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

580384

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

580385

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

580388

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

580390

ANM2
Protein arginine N-methyltransferase 2

1

1

Small-scale

0.479

High

580392

1433Z
14-3-3 protein zeta/delta

1

3

Small-scale

0.479

High

580393

DYST
Dystonin

1

2

High-throughput

0.479

High

580394

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.479

High

580404

ASB18
Ankyrin repeat and SOCS box protein 18

1

1

High-throughput

0.479

High

580405

ASB5
Ankyrin repeat and SOCS box protein 5

1

1

High-throughput

0.479

High

580407

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

580408

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

580409

ASB9
Ankyrin repeat and SOCS box protein 9

1

2

High-throughput

0.479

High

580412

NECD
Necdin

1

1

High-throughput

0.479

High

580413

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

580415

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

580419

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

407785

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

321956

NFAT5
Nuclear factor of activated T-cells 5

1

0

Small-scale

0.458

High

379856

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

411295

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

580380

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

580382

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

580383

PAX7
Paired box protein Pax-7

1

0

High-throughput

0.458

High

580387

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

580395

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

580397

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

580401

CBPC2
Cytosolic carboxypeptidase 2

1

0

High-throughput

0.458

High

580402

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

580418

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

580411

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.457

High

529000

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

580416

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

580403

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

563123

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

580406

BSND
Barttin

1

0

High-throughput

0.279

Low

105258

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

239707

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

276735

ZN253
Zinc finger protein 253

1

0

High-throughput

0.249

Low

580410

CSMD1
CUB and sushi domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025