HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 545 Hs			1 304
+	Hs
		217439 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		217465 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		217436 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		802690 PF21A_HUMAN (130-352): 7.15e-33: 135: 23.38		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		617255 SP100_HUMAN (3-296): 1.81e-36: 146: 13.81		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		802886 PF21A_HUMAN (130-352): 7.15e-33: 135: 23.38		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		548752 SP110_HUMAN (2-297): 4.05e-35: 142: 16.77		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		331715 NSD2_HUMAN (30-345): 3.09e-17: 87.5: 14.80		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00