HitPredict

Interactor 1: SMD3 (O44437)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SMD3

Interactor 2: Q9VJI7 (Q9VJI7)
GEO08441p1 (Like Sm 7, isoform A) (Like Sm 7, isoform B) (Like Sm 7, isoform C) (RH73529p)
Gene: LSm7

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	14605208, 20353594
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005689 - U12-type spliceosomal complex GO:0071011 - precatalytic spliceosome GO:0071013 - catalytic step 2 spliceosome and 1 others more... GO:0097526 - spliceosomal tri-snRNP complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 151 Dm			1 110
+	Dm
		1368675 Q9VKW8_DROME (5-136): 1.95e-38: 129: 26.76		Q9VJI7_DROME (1-110): 5.99e-39: 127: 100.00
+	Hs
		912752 SMD3_HUMAN (1-106): 4.39e-38: 127: 83.96		LSM7_HUMAN (13-110): 5.95e-34: 114: 76.53
+	Hs
		1356296 LSM4_HUMAN (5-135): 1.18e-36: 124: 29.20		LSM7_HUMAN (13-110): 5.95e-34: 114: 76.53
+	Hs
		912142 SMD3_HUMAN (1-106): 4.39e-38: 127: 83.96		LSM3_HUMAN (1-96): 2.86e-25: 92.7: 27.72
+	Hs
		912611 SMD3_HUMAN (1-106): 4.39e-38: 127: 83.96		RSMN_HUMAN (24-95): 1.04e-23: 92.7: 27.40
+	Hs
		538896 SMD3_HUMAN (1-106): 4.39e-38: 127: 83.96		RSMB_HUMAN (24-95): 2.4e-23: 91.5: 27.40
+	Dm
		218359 SMD3_DROME (1-139): 1.15e-36: 125: 100.00		RSMB_DROME (24-95): 1.98e-24: 93.4: 26.03
+	Hs
		912211 LSM4_HUMAN (5-135): 1.18e-36: 124: 29.20		LSM3_HUMAN (1-96): 2.86e-25: 92.7: 27.72
+	Hs
		928049 LSM4_HUMAN (5-135): 1.18e-36: 124: 29.20		RSMN_HUMAN (24-95): 1.04e-23: 92.7: 27.40
+	Hs
		912024 SMD3_HUMAN (1-106): 4.39e-38: 127: 83.96		RUXG_HUMAN (18-100): 2.34e-24: 89.6: 32.53
+	Hs
		539204 LSM4_HUMAN (5-135): 1.18e-36: 124: 29.20		RSMB_HUMAN (24-95): 2.4e-23: 91.5: 27.40
+	Dm
		1213197 Q9VKW8_DROME (5-136): 1.95e-38: 129: 26.76		Q8IMX8_DROME (1-96): 1.15e-22: 86.1: 24.75
+	Hs
		321390 SMD3_HUMAN (1-106): 4.39e-38: 127: 83.96		LSM8_HUMAN (24-107): 4.09e-23: 87.3: 28.57
+	Dm
		1369698 Q9VKW8_DROME (5-136): 1.95e-38: 129: 26.76		Q9W087_DROME (24-108): 2.96e-22: 85: 23.53
+	Dm
		218379 SMD3_DROME (1-139): 1.15e-36: 125: 100.00		RUXG_DROME (18-100): 1.26e-23: 87.7: 34.94
+	At
		1323437 SMD1B_ARATH (7-102): 2.4e-35: 120: 20.83		Q9FI15_ARATH (24-95): 2.58e-23: 91.9: 25.00
+	Hs
		321444 LSM4_HUMAN (5-135): 1.18e-36: 124: 29.20		LSM8_HUMAN (24-107): 4.09e-23: 87.3: 28.57
+	Hs
		68411 SMD3_HUMAN (1-106): 4.39e-38: 127: 83.96		RUXGL_HUMAN (18-100): 3.57e-22: 84.2: 31.33
+	Hs
		167728 LSM4_HUMAN (5-135): 1.18e-36: 124: 29.20		LSM1_HUMAN (23-109): 3.21e-22: 85.7: 26.44
+	At
		1352883 SMD1B_ARATH (7-102): 2.4e-35: 120: 20.83		Q9SUN5_ARATH (24-95): 1.61e-22: 89.6: 25.33