Protein: MYCB2
E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc)

Gene: MYCB2, MYCBP2
Organism: Homo sapiens
Interactions: 238
UniProt ID: O75592

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

287988

FBXW7
F-box/WD repeat-containing protein 7

7

8

Small-scale

0.956

High

287907

RAE1L
mRNA export factor RAE1

2

6

High-throughput

0.754

High

287917

CUL3
Cullin-3

2

20

High-throughput

0.754

High

287853

FBSP1
F-box/SPRY domain-containing protein 1

7

16

Small-scale

0.749

High

287899

1433G
14-3-3 protein gamma

6

20

High-throughput

0.730

High

287910

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

287872

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.709

High

287913

LG3BP
Galectin-3-binding protein

4

4

High-throughput

0.697

High

287902

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.694

High

287918

CUL4B
Cullin-4B

1

20

High-throughput

0.691

High

287975

WDR48
WD repeat-containing protein 48

1

9

High-throughput

0.691

High

287903

SKP1
S-phase kinase-associated protein 1

4

8

Small-scale

0.691

High

287868

1433T
14-3-3 protein theta

4

20

Small-scale

0.689

High

287842

MYC
Myc proto-oncogene protein

3

5

Small-scale

0.675

High

287961

SKAP1
Src kinase-associated phosphoprotein 1

3

6

High-throughput

0.667

High

288044

CLC11
C-type lectin domain family 11 member A

4

0

High-throughput

0.661

High

287857

TDGF1
Protein Cripto

3

0

High-throughput

0.638

High

287894

SESN3
Sestrin-3

3

0

High-throughput

0.638

High

287947

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

3

2

Small-scale

0.633

High

288008

NMNA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

3

0

Small-scale

0.632

High

287843

PDGFB
Platelet-derived growth factor subunit B

2

1

High-throughput

0.628

High

287981

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

1

High-throughput

0.628

High

288014

TXNIP
Thioredoxin-interacting protein

2

4

High-throughput

0.628

High

288023

DOCK5
Dedicator of cytokinesis protein 5

2

4

High-throughput

0.628

High

288038

CTNA3
Catenin alpha-3

2

2

High-throughput

0.628

High

287871

EPHB2
Ephrin type-B receptor 2

2

2

High-throughput

0.618

High

287835

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

8

High-throughput

0.618

High

287932

RBBP7
Histone-binding protein RBBP7

1

5

High-throughput

0.618

High

287949

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.618

High

287973

COP1
E3 ubiquitin-protein ligase COP1

1

15

High-throughput

0.618

High

287898

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.611

High

169227

CASQ2
Calsequestrin-2

2

1

High-throughput

0.611

High

287863

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

2

4

High-throughput

0.611

High

287889

PLK1
Serine/threonine-protein kinase PLK1

2

6

High-throughput

0.611

High

287900

1433E
14-3-3 protein epsilon

2

1

High-throughput

0.611

High

288011

CAD19
Cadherin-19

2

4

High-throughput

0.611

High

288027

NGRN
Neugrin

2

1

High-throughput

0.611

High

288041

HECD1
E3 ubiquitin-protein ligase HECTD1

2

14

High-throughput

0.611

High

288053

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

2

1

Small-scale

0.611

High

287888

STAT2
Signal transducer and activator of transcription 2

2

0

High-throughput

0.602

High

287909

GCYB1
Guanylate cyclase soluble subunit beta-1

2

0

High-throughput

0.602

High

287914

CETN1
Centrin-1

2

0

High-throughput

0.602

High

287997

PGBD1
PiggyBac transposable element-derived protein 1

2

0

High-throughput

0.602

High

287873

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

287994

HIPL1
HHIP-like protein 1

2

3

High-throughput

0.601

High

287884

TSC2
Tuberin

2

6

Small-scale

0.596

High

287904

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

20

Small-scale

0.595

High

287878

CCNF
Cyclin-F

2

7

High-throughput

0.584

High

287862

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

4

High-throughput

0.576

High

287986

GGH
Gamma-glutamyl hydrolase

2

0

High-throughput

0.576

High

287892

GDF10
Growth/differentiation factor 10

2

3

High-throughput

0.574

High

287963

DRC2
Dynein regulatory complex subunit 2

2

2

High-throughput

0.574

High

287864

IBP4
Insulin-like growth factor-binding protein 4

2

1

High-throughput

0.549

High

287895

INHBE
Inhibin beta E chain

2

2

High-throughput

0.549

High

161582

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

9

High-throughput

0.541

High

287848

LDHB
L-lactate dehydrogenase B chain

1

1

High-throughput

0.541

High

287849

HS90B
Heat shock protein HSP 90-beta

1

10

High-throughput

0.541

High

287852

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

3

High-throughput

0.541

High

287865

COF1
Cofilin-1

1

2

High-throughput

0.541

High

287875

SPB6
Serpin B6

1

1

High-throughput

0.541

High

287893

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

3

High-throughput

0.541

High

287897

CD81
CD81 antigen

1

1

High-throughput

0.541

High

287919

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.541

High

287920

FHL3
Four and a half LIM domains protein 3

1

3

High-throughput

0.541

High

287921

BTG3
Protein BTG3

1

1

High-throughput

0.541

High

287934

TBR1
T-box brain protein 1

1

1

High-throughput

0.541

High

287948

TBC9B
TBC1 domain family member 9B

1

1

High-throughput

0.541

High

287958

PABP2
Polyadenylate-binding protein 2

1

2

High-throughput

0.541

High

287971

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.541

High

287982

RSPH1
Radial spoke head 1 homolog

1

4

High-throughput

0.541

High

287983

TITIN
Titin

1

6

High-throughput

0.541

High

287995

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.541

High

288022

ASB8
Ankyrin repeat and SOCS box protein 8

1

10

High-throughput

0.541

High

288029

AT132
Polyamine-transporting ATPase 13A2

1

2

Small-scale

0.541

High

288032

AATF
Protein AATF

1

1

High-throughput

0.541

High

288037

PUF60
Poly(U)-binding-splicing factor PUF60

1

6

High-throughput

0.541

High

288039

DP13A
DCC-interacting protein 13-alpha

1

1

High-throughput

0.541

High

74414

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.536

High

287836

SVIL
Supervillin

1

6

High-throughput

0.536

High

287837

PIGN
GPI ethanolamine phosphate transferase 1

1

1

High-throughput

0.536

High

287861

NR1D1
Nuclear receptor subfamily 1 group D member 1

1

3

Small-scale

0.536

High

287870

MAP4
Microtubule-associated protein 4

1

7

High-throughput

0.536

High

287887

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

9

High-throughput

0.536

High

287891

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.536

High

287905

TBB4B
Tubulin beta-4B chain

1

11

High-throughput

0.536

High

287925

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.536

High

287926

CBX2
Chromobox protein homolog 2

1

5

High-throughput

0.536

High

287928

EEA1
Early endosome antigen 1

1

7

High-throughput

0.536

High

287936

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.536

High

287978

CKAP2
Cytoskeleton-associated protein 2

1

1

High-throughput

0.536

High

287992

HDA11
Histone deacetylase 11

1

8

High-throughput

0.536

High

288021

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

288034

PCD10
Protocadherin-10

1

5

High-throughput

0.536

High

288048

PCDB6
Protocadherin beta-6

1

5

High-throughput

0.536

High

288052

PCDA3
Protocadherin alpha-3

1

5

High-throughput

0.536

High

287834

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.518

High

287841

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.518

High

287881

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.518

High

287890

OAZ1
Ornithine decarboxylase antizyme 1

1

0

High-throughput

0.518

High

287935

FSCN1
Fascin

1

0

High-throughput

0.518

High

288004

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.518

High

288016

CUED2
CUE domain-containing protein 2

1

0

High-throughput

0.518

High

288035

PI4KB
Phosphatidylinositol 4-kinase beta

1

0

High-throughput

0.518

High

287933

BAK
Bcl-2 homologous antagonist/killer

1

1

High-throughput

0.515

High

192532

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

287879

WNT5A
Protein Wnt-5a

1

0

High-throughput

0.513

High

287880

MMP13
Collagenase 3

1

0

High-throughput

0.513

High

287908

NDP
Norrin

1

0

High-throughput

0.513

High

287912

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.513

High

287930

TESK1
Dual specificity testis-specific protein kinase 1

1

0

High-throughput

0.513

High

287941

VP26B
Vacuolar protein sorting-associated protein 26B

1

0

High-throughput

0.513

High

287946

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

287953

RBPS2
RNA-binding protein with multiple splicing 2

1

0

High-throughput

0.513

High

287972

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.513

High

287974

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.513

High

287991

SKA1
SKA complex subunit 1

1

0

High-throughput

0.513

High

288001

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

288002

CSRN1
Cysteine/serine-rich nuclear protein 1

1

0

High-throughput

0.513

High

288006

TLR10
Toll-like receptor 10

1

0

High-throughput

0.513

High

288007

ABCA2
ATP-binding cassette sub-family A member 2

1

0

High-throughput

0.513

High

288013

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

0

High-throughput

0.513

High

288033

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.513

High

287901

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.501

High

287906

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.501

High

287867

IBP6
Insulin-like growth factor-binding protein 6

1

1

High-throughput

0.494

High

287923

SPRL1
SPARC-like protein 1

1

1

High-throughput

0.494

High

287954

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.494

High

287970

SPRY3
SPRY domain-containing protein 3

1

2

High-throughput

0.494

High

287929

PDIA6
Protein disulfide-isomerase A6

1

0

High-throughput

0.493

High

287882

TFPI2
Tissue factor pathway inhibitor 2

1

1

High-throughput

0.489

High

287957

ALPK2
Alpha-protein kinase 2

1

6

High-throughput

0.489

High

287962

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

1

High-throughput

0.489

High

287979

OIT3
Oncoprotein-induced transcript 3 protein

1

1

High-throughput

0.489

High

288018

CSTN2
Calsyntenin-2

1

4

High-throughput

0.489

High

122685

KIF2A
Kinesin-like protein KIF2A

1

4

Small-scale

0.479

High

129624

CBX4
E3 SUMO-protein ligase CBX4

1

5

High-throughput

0.479

High

136034

PLK4
Serine/threonine-protein kinase PLK4

1

7

High-throughput

0.479

High

168021

RGS12
Regulator of G-protein signaling 12

1

2

Small-scale

0.479

High

169855

AURKA
Aurora kinase A

1

9

High-throughput

0.479

High

217615

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

246350

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.479

High

287838

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

287840

NSD2
Histone-lysine N-methyltransferase NSD2

1

8

Small-scale

0.479

High

287845

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.479

High

287851

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

287854

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

High-throughput

0.479

High

287855

ANDR
Androgen receptor

1

12

High-throughput

0.479

High

287858

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

287869

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

287874

NOS2
Nitric oxide synthase, inducible

1

1

High-throughput

0.479

High

287876

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

287877

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.479

High

287885

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

287886

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.479

High

287911

UBE3A
Ubiquitin-protein ligase E3A

1

17

Small-scale

0.479

High

287915

STK3
Serine/threonine-protein kinase 3

1

6

Small-scale

0.479

High

287916

HDAC1
Histone deacetylase 1

1

6

High-throughput

0.479

High

287922

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

2

High-throughput

0.479

High

287927

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

287931

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

287937

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

287940

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

287955

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

287956

DNJB7
DnaJ homolog subfamily B member 7

1

5

High-throughput

0.479

High

287965

LIRA3
Leukocyte immunoglobulin-like receptor subfamily A member 3

1

2

High-throughput

0.479

High

287966

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

287968

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

287977

LNX1
E3 ubiquitin-protein ligase LNX

1

5

Small-scale

0.479

High

287980

ASB11
Ankyrin repeat and SOCS box protein 11

1

6

High-throughput

0.479

High

287984

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

287985

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

287987

ATOH1
Transcription factor ATOH1

1

4

Small-scale

0.479

High

287990

PF21A
PHD finger protein 21A

1

3

High-throughput

0.479

High

287996

NEUL4
Neuralized-like protein 4

1

3

High-throughput

0.479

High

288005

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.479

High

288009

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

288010

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

288015

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

288019

DEFI6
Differentially expressed in FDCP 6 homolog

1

6

High-throughput

0.479

High

288020

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.479

High

288024

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

288026

MYO10
Unconventional myosin-X

1

1

Small-scale

0.479

High

288028

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.479

High

288030

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

288036

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

288040

RCOR1
REST corepressor 1

1

1

High-throughput

0.479

High

288042

CC14A
Dual specificity protein phosphatase CDC14A

1

7

High-throughput

0.479

High

288043

FAF1
FAS-associated factor 1

1

4

High-throughput

0.479

High

288046

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

7

Small-scale

0.479

High

276803

VATG1
V-type proton ATPase subunit G 1

1

0

High-throughput

0.458

High

287846

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.458

High

287860

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

287924

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

287939

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

0

High-throughput

0.458

High

287960

SERC5
Serine incorporator 5

1

0

Small-scale

0.458

High

287976

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.458

High

287999

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

287856

CLUS
Clusterin

1

1

High-throughput

0.457

High

288031

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

126934

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

287847

FYN
Tyrosine-protein kinase Fyn

1

5

High-throughput

0.445

High

287859

VINC
Vinculin

1

3

High-throughput

0.445

High

287938

ASTRB
Protein Aster-B

1

2

High-throughput

0.445

High

287942

KLH22
Kelch-like protein 22

1

2

High-throughput

0.445

High

287959

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

2

High-throughput

0.445

High

287967

PCD20
Protocadherin-20

1

5

High-throughput

0.445

High

287998

Q96KY9
CDH19 protein

1

5

High-throughput

0.445

High

288000

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.445

High

288017

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

7

High-throughput

0.445

High

288049

PCDGE
Protocadherin gamma-B2

1

4

High-throughput

0.445

High

288050

PCDG5
Protocadherin gamma-A5

1

4

High-throughput

0.445

High

288051

PCDA8
Protocadherin alpha-8

1

4

High-throughput

0.445

High

104690

F6VUV4
Dehydrogenase/reductase 4 like 2

1

2

High-throughput

0.439

High

287993

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

91834

ANR63
Ankyrin repeat domain-containing protein 63

1

9

High-throughput

0.437

High

287839

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

287944

CD158
Coiled-coil domain-containing protein 158

1

6

High-throughput

0.437

High

287866

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

287964

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.426

High

287989

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.426

High

288045

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

288055

ICOS
Inducible T-cell costimulator

1

0

Small-scale

0.426

High

287896

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

287950

DR4L2
Dehydrogenase/reductase SDR family member 4-like 2

1

2

High-throughput

0.417

High

287883

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

287952

ACP7
Acid phosphatase type 7

2

0

High-throughput

0.324

High

288047

INSL6
Insulin-like peptide INSL6

2

0

High-throughput

0.313

High

288054

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.282

High

287844

C1QB
Complement C1q subcomponent subunit B

1

0

High-throughput

0.279

Low

287850

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.279

Low

287943

PLA1A
Phospholipase A1 member A

1

0

High-throughput

0.279

Low

287945

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.279

Low

287951

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.279

Low

287969

PGLT1
Protein O-glucosyltransferase 1

1

0

High-throughput

0.279

Low

288012

IL25
Interleukin-25

1

0

High-throughput

0.279

Low

66102

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.249

Low

288025

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

288003

HPLN3
Hyaluronan and proteoglycan link protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025