HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: CYFP2 (Q96F07)
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Gene: CYFIP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	26186194, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 1278
+	Hs
		594077 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		222126 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		594033 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		463701 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		463192 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		557427 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		987855 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		463609 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Mm
		686976 P85A_MOUSE (166-379): 9.21e-25: 107: 16.36		CYFP1_MOUSE (1-1277): 0: 2032: 85.68
+	Hs
		463137 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		557357 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Dm
		1061451 GRAP_DROME (204-368): 9.23e-17: 80.1: 30.72		CYFIP_DROME (1-1277): 0: 1898: 64.75