HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SIK2 (Q9H0K1)
Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
Gene: SIK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 926
+	Hs
		699848 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		SIK2_HUMAN (1-926): 0: 734: 100.00
+	Hs
		463219 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		SIK2_HUMAN (1-926): 0: 734: 100.00
+	Hs
		593917 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		MARK3_HUMAN (8-677): 3.85e-150: 463: 30.47
+	Hs
		594121 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		MARK1_HUMAN (15-677): 1.02e-149: 463: 30.94
+	Hs
		463345 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MARK3_HUMAN (8-677): 3.85e-150: 463: 30.47
+	Hs
		463607 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MARK2_HUMAN (1-673): 2.66e-146: 454: 31.29
+	Hs
		439960 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		MARK3_HUMAN (8-677): 3.85e-150: 463: 30.47
+	Hs
		440528 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		AAPK1_HUMAN (3-526): 3.85e-149: 454: 30.74
+	Hs
		440132 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		MARK2_HUMAN (1-673): 2.66e-146: 454: 31.29
+	Hs
		463709 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MARK4_HUMAN (15-497): 4.79e-140: 437: 41.02