HitPredict

Interactor 1: ARHG7 (O55043)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta)
Gene: Arhgef7

Interactor 2: SHAN2 (Q9QX74)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3)
Gene: Shank2

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12626503
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ_6~betaPIX_CC, SH3_2~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0030426 - growth cone GO:0043005 - neuron projection GO:0043025 - neuronal cell body
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 646 Rn			1 1474
+	Hs
		1049744 ARHG7_HUMAN (1-593): 7.61e-162: 486: 88.22		SHAN2_HUMAN (13-1474): 2.34e-180: 587: 89.06
+	Rn
		223053 ARHG7_RAT (1-646): 2.96e-175: 515: 100.00		SHAN3_RAT (13-1471): 3.07e-78: 288: 32.82
+	Hs
		1049728 ARHG7_HUMAN (1-593): 7.61e-162: 486: 88.22		SHAN3_HUMAN (13-1471): 4.47e-82: 300: 32.79
+	Mm
		1116136 ARHG7_MOUSE (1-646): 2.22e-152: 463: 83.83		SHAN3_MOUSE (13-1471): 3.95e-82: 301: 33.11
+	Hs
		1049746 ARHG7_HUMAN (1-593): 7.61e-162: 486: 88.22		MAST1_HUMAN (14-871): 1.01e-42: 173: 14.38
+	Hs
		1066060 ARHG6_HUMAN (1-645): 1.91e-156: 471: 60.43		MAST1_HUMAN (14-871): 1.01e-42: 173: 14.38
+	Hs
		1049725 ARHG7_HUMAN (1-593): 7.61e-162: 486: 88.22		SNX27_HUMAN (248-478): 1.13e-37: 151: 22.94
+	Mm
		1115909 SPT13_MOUSE (6-481): 6.69e-101: 323: 21.43		SHAN3_MOUSE (13-1471): 3.95e-82: 301: 33.11
+	Rn
		223055 ARHG7_RAT (1-646): 2.96e-175: 515: 100.00		SHAN1_RAT (376-1412): 1.5e-12: 75: 13.08
+	Hs
		1049748 ARHG7_HUMAN (1-593): 7.61e-162: 486: 88.22		SHAN1_HUMAN (352-1474): 6.95e-21: 102: 13.07
+	Hs
		1078902 ITSN1_HUMAN (2-411): 8.79e-80: 278: 17.61		SHAN3_HUMAN (13-1471): 4.47e-82: 300: 32.79
+	Mm
		57847 KALRN_MOUSE (32-472): 1.34e-62: 227: 15.08		SHAN3_MOUSE (13-1471): 3.95e-82: 301: 33.11
+	Rn
		94299 TRIO_RAT (47-601): 4.37e-63: 229: 13.08		SI1L1_RAT (207-932): 6.26e-41: 168: 15.38
+	Mm
		57867 KALRN_MOUSE (32-472): 1.34e-62: 227: 15.08		SI1L1_MOUSE (207-932): 7.33e-40: 164: 15.38
+	Hs
		1022476 TIAM1_HUMAN (60-278): 1.59e-11: 69.7: 26.16		MAST1_HUMAN (14-871): 1.01e-42: 173: 14.38
+	Hs
		196437 TIAM1_HUMAN (60-278): 1.59e-11: 69.7: 26.16		SI1L1_HUMAN (207-1000): 4.9e-39: 161: 14.72
+	Hs
		230868 TIAM1_HUMAN (60-278): 1.59e-11: 69.7: 26.16		MAST3_HUMAN (75-635): 2.34e-32: 139: 15.59