HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: TCPH (Q99832)
T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]
Gene: CCT7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 328 Hs			1 543
+	Hs
		224241 BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00		TCPG_HUMAN (1-541): 0: 577: 31.09
+	At
		1441694 BUB31_ARATH (1-324): 2.9e-85: 262: 52.89		TCPH_ARATH (1-529): 0: 583: 67.67
+	At
		146732 RAE1_ARATH (3-324): 3.49e-96: 290: 38.32		TCPE_ARATH (3-524): 0: 551: 30.70
+	Hs
		224239 BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		224224 BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00		TCPA_HUMAN (2-533): 0: 544: 34.54
+	At
		100104 BUB33_ARATH (1-316): 1.87e-74: 233: 32.08		TCPH_ARATH (1-529): 0: 583: 67.67
+	Hs
		1407594 NLE1_HUMAN (86-320): 5.73e-48: 169: 13.03		TCPH_HUMAN (1-543): 0: 647: 100.00
+	Hs
		882075 FBXW7_HUMAN (1-202): 4.67e-46: 167: 20.38		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		845257 LIS1_HUMAN (1-165): 8.61e-43: 154: 15.71		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		876199 NLE1_HUMAN (86-320): 5.73e-48: 169: 13.03		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		882051 POC1B_HUMAN (134-327): 4.58e-40: 148: 13.73		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		610813 FBXW7_HUMAN (1-202): 4.67e-46: 167: 20.38		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Hs
		876081 POC1B_HUMAN (134-327): 4.58e-40: 148: 13.73		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		610789 POC1B_HUMAN (134-327): 4.58e-40: 148: 13.73		TCPA_HUMAN (2-533): 0: 544: 34.54
+	At
		705043 RAE1_ARATH (3-324): 3.49e-96: 290: 38.32		TCPA_ARATH (14-521): 1.16e-93: 298: 36.67
+	At
		1182582 RAE1_ARATH (3-324): 3.49e-96: 290: 38.32		TCPB_ARATH (8-528): 1.6e-88: 284: 35.36
+	Hs
		224247 BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00		TCPD_HUMAN (24-520): 4.06e-90: 288: 33.79
+	At
		705050 BUB31_ARATH (1-324): 2.9e-85: 262: 52.89		TCPA_ARATH (14-521): 1.16e-93: 298: 36.67
+	At
		100091 BUB33_ARATH (1-316): 1.87e-74: 233: 32.08		TCPA_ARATH (14-521): 1.16e-93: 298: 36.67
+	Hs
		899608 NLE1_HUMAN (86-320): 5.73e-48: 169: 13.03		TCPD_HUMAN (24-520): 4.06e-90: 288: 33.79