Protein: BUB3
Mitotic checkpoint protein BUB3

Gene: BUB3
Organism: Homo sapiens
Interactions: 238
UniProt ID: O43684

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0007094 - mitotic spindle assembly checkpoint signaling
GO:0008608 - attachment of spindle microtubules to kinetochore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

224189

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

32

16

Small-scale

0.994

High

224058

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

10

13

Small-scale

0.978

High

224391

APC4
Anaphase-promoting complex subunit 4

8

1

Small-scale

0.960

High

224264

TCPB
T-complex protein 1 subunit beta

4

20

High-throughput

0.903

High

224277

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

4

5

Small-scale

0.878

High

224239

TCPE
T-complex protein 1 subunit epsilon

3

20

High-throughput

0.871

High

224247

TCPD
T-complex protein 1 subunit delta

3

20

High-throughput

0.871

High

224350

TCPH
T-complex protein 1 subunit eta

3

20

High-throughput

0.861

High

224224

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.811

High

224235

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.811

High

224241

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.811

High

224246

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.811

High

224260

ACTA
Actin, aortic smooth muscle

2

10

High-throughput

0.811

High

224332

TCPW
T-complex protein 1 subunit zeta-2

2

20

High-throughput

0.811

High

224272

CDC20
Cell division cycle protein 20 homolog

14

20

Small-scale

0.758

High

224298

EZH2
Histone-lysine N-methyltransferase EZH2

2

20

High-throughput

0.754

High

223474

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

8

13

Small-scale

0.751

High

224230

CDC27
Cell division cycle protein 27 homolog

8

9

Small-scale

0.747

High

224199

UBR5
E3 ubiquitin-protein ligase UBR5

6

9

Small-scale

0.729

High

224301

RBBP7
Histone-binding protein RBBP7

1

19

Small-scale

0.724

High

224245

DYN2
Dynamin-2

1

4

High-throughput

0.691

High

224250

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

High-throughput

0.691

High

224282

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.691

High

224337

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

16

High-throughput

0.691

High

224331

PHIP
PH-interacting protein

2

19

Small-scale

0.675

High

224353

BTBDA
BTB/POZ domain-containing protein 10

3

1

High-throughput

0.667

High

224389

CDC23
Cell division cycle protein 23 homolog

3

10

High-throughput

0.662

High

224205

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.640

High

224187

ZC3H1
Zinc finger C3H1 domain-containing protein

4

1

High-throughput

0.638

High

224328

KNL1
Outer kinetochore KNL1 complex subunit KNL1

2

2

High-throughput

0.628

High

224255

ATX1
Ataxin-1

2

2

High-throughput

0.621

High

224304

ACTBL
Beta-actin-like protein 2

1

9

High-throughput

0.618

High

139444

PESC
Pescadillo homolog

1

1

Small-scale

0.618

High

156728

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.618

High

159425

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

High-throughput

0.618

High

161377

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.618

High

175815

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

High-throughput

0.618

High

224196

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.618

High

224200

HERC2
E3 ubiquitin-protein ligase HERC2

1

7

High-throughput

0.618

High

224242

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

5

High-throughput

0.618

High

224259

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.618

High

224261

H4
Histone H4

1

7

High-throughput

0.618

High

224263

H31
Histone H3.1

1

10

High-throughput

0.618

High

224269

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.618

High

224287

BOP1
Ribosome biogenesis protein BOP1

1

19

Small-scale

0.618

High

224290

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.618

High

224292

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.618

High

224295

RBBP5
Retinoblastoma-binding protein 5

1

20

High-throughput

0.618

High

224300

DDB1
DNA damage-binding protein 1

1

10

Small-scale

0.618

High

224309

PRP8
Pre-mRNA-processing-splicing factor 8

1

6

High-throughput

0.618

High

224325

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.618

High

224355

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

8

High-throughput

0.618

High

224372

ANLN
Anillin

1

3

High-throughput

0.618

High

224376

NLE1
Notchless protein homolog 1

1

18

High-throughput

0.618

High

224378

DTL
Denticleless protein homolog

1

18

Small-scale

0.618

High

224397

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.618

High

224399

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.618

High

224402

TRRAP
Transformation/transcription domain-associated protein

1

8

High-throughput

0.618

High

224258

WDR5
WD repeat-containing protein 5

2

19

High-throughput

0.611

High

224284

CUL3
Cullin-3

2

20

High-throughput

0.611

High

224315

KCD20
BTB/POZ domain-containing protein KCTD20

3

1

High-throughput

0.609

High

224321

NKAP
NF-kappa-B-activating protein

2

0

Small-scale

0.605

High

224340

APC16
Anaphase-promoting complex subunit 16

2

0

High-throughput

0.585

High

128642

MEN1
Menin

2

4

High-throughput

0.584

High

224186

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.584

High

224215

PARP1
Poly [ADP-ribose] polymerase 1

2

6

Small-scale

0.584

High

224229

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

5

High-throughput

0.584

High

224233

RFA3
Replication protein A 14 kDa subunit

2

3

High-throughput

0.584

High

224234

BRCA1
Breast cancer type 1 susceptibility protein

2

11

High-throughput

0.584

High

224271

EP300
Histone acetyltransferase p300

2

13

High-throughput

0.584

High

224316

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

6

High-throughput

0.584

High

224308

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.575

High

220724

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

1

High-throughput

0.573

High

224211

JUN
Transcription factor Jun

2

15

High-throughput

0.571

High

224206

FINC
Fibronectin

1

4

High-throughput

0.553

High

224310

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

224365

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.553

High

224217

TAU
Microtubule-associated protein tau

2

19

High-throughput

0.552

High

224190

EXOC3
Exocyst complex component 3

1

1

High-throughput

0.541

High

224218

THA
Thyroid hormone receptor alpha

1

12

High-throughput

0.541

High

224257

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.541

High

224349

CPNE1
Copine-1

1

1

High-throughput

0.541

High

135416

DNM1L
Dynamin-1-like protein

1

4

High-throughput

0.536

High

213726

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

224216

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

10

High-throughput

0.536

High

224281

HDAC1
Histone deacetylase 1

1

10

Small-scale

0.536

High

224294

RNPS1
RNA-binding protein with serine-rich domain 1

1

12

High-throughput

0.536

High

224327

ARI1B
AT-rich interactive domain-containing protein 1B

1

16

High-throughput

0.536

High

224330

RIN3
Ras and Rab interactor 3

1

7

High-throughput

0.536

High

224335

HDAC2
Histone deacetylase 2

1

10

Small-scale

0.536

High

224336

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.536

High

224345

CDC5L
Cell division cycle 5-like protein

1

12

High-throughput

0.536

High

224384

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

16

High-throughput

0.536

High

224193

WBP4
WW domain-binding protein 4

1

6

High-throughput

0.527

High

224225

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.521

High

224351

SH3G3
Endophilin-A3

2

1

High-throughput

0.521

High

224312

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.517

High

224265

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.515

High

224297

SMAD2
Mothers against decapentaplegic homolog 2

1

6

Small-scale

0.515

High

224371

LZTL1
Leucine zipper transcription factor-like protein 1

1

0

High-throughput

0.513

High

224375

INT7
Integrator complex subunit 7

1

0

High-throughput

0.513

High

224251

DYLT3
Dynein light chain Tctex-type 3

1

4

Small-scale

0.501

High

224256

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.501

High

224306

RAIN
Ras-interacting protein 1

1

9

High-throughput

0.489

High

224317

ST32C
Serine/threonine-protein kinase 32C

1

3

High-throughput

0.489

High

224347

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.489

High

224203

CHK2
Serine/threonine-protein kinase Chk2

1

5

Small-scale

0.484

High

224227

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.481

High

224359

REXO4
RNA exonuclease 4

1

2

High-throughput

0.481

High

224400

SGT1
Protein SGT1 homolog

1

5

High-throughput

0.481

High

131602

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

137871

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

Small-scale

0.479

High

158060

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.479

High

172296

XPO1
Exportin-1

1

14

High-throughput

0.479

High

194489

KDM6A
Lysine-specific demethylase 6A

1

16

High-throughput

0.479

High

224188

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

224192

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

224195

RNF8
E3 ubiquitin-protein ligase RNF8

1

8

High-throughput

0.479

High

224197

ST17B
Serine/threonine-protein kinase 17B

1

4

High-throughput

0.479

High

224198

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

224201

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

15

High-throughput

0.479

High

224204

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

224207

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

224210

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

224212

GLI1
Zinc finger protein GLI1

1

3

Small-scale

0.479

High

224213

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

224220

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.479

High

224222

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

224223

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

224226

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

224228

APC
Adenomatous polyposis coli protein

1

18

Small-scale

0.479

High

224231

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

224232

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

224236

GATA4
Transcription factor GATA-4

1

5

Small-scale

0.479

High

224237

MAP1B
Microtubule-associated protein 1B

1

15

High-throughput

0.479

High

224238

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

224240

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

224244

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.479

High

224248

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

224249

HCFC1
Host cell factor 1

1

8

High-throughput

0.479

High

224252

HDGF
Hepatoma-derived growth factor

1

9

High-throughput

0.479

High

224254

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.479

High

224262

YBOX1
Y-box-binding protein 1

1

4

Small-scale

0.479

High

224267

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.479

High

224268

KIF23
Kinesin-like protein KIF23

1

10

High-throughput

0.479

High

224273

TP53B
TP53-binding protein 1

1

7

High-throughput

0.479

High

224274

FOXC1
Forkhead box protein C1

1

6

High-throughput

0.479

High

224276

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

2

High-throughput

0.479

High

224278

IKZF1
DNA-binding protein Ikaros

1

6

High-throughput

0.479

High

224279

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

224280

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

224283

CUL2
Cullin-2

1

20

Small-scale

0.479

High

224285

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

224286

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

224289

IMB1
Importin subunit beta-1

1

9

Small-scale

0.479

High

224291

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

224293

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

224296

SF3A2
Splicing factor 3A subunit 2

1

8

High-throughput

0.479

High

224311

PAXI1
PAX-interacting protein 1

1

16

High-throughput

0.479

High

224313

KANL1
KAT8 regulatory NSL complex subunit 1

1

4

High-throughput

0.479

High

224320

SLX4
Structure-specific endonuclease subunit SLX4

1

15

High-throughput

0.479

High

224322

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

224323

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

224326

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

17

High-throughput

0.479

High

224333

TOPB1
DNA topoisomerase 2-binding protein 1

1

12

High-throughput

0.479

High

224334

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

224338

FUBP1
Far upstream element-binding protein 1

1

19

High-throughput

0.479

High

224339

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

224343

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

224344

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

224346

NECD
Necdin

1

9

High-throughput

0.479

High

224348

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

224352

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

224354

TRI31
E3 ubiquitin-protein ligase TRIM31

1

11

High-throughput

0.479

High

224360

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

224363

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

224366

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

224367

KANL2
KAT8 regulatory NSL complex subunit 2

1

2

High-throughput

0.479

High

224368

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

224369

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.479

High

224370

BRD7
Bromodomain-containing protein 7

1

16

High-throughput

0.479

High

224373

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

224379

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

High-throughput

0.479

High

224381

CXXC1
CXXC-type zinc finger protein 1

1

18

High-throughput

0.479

High

224382

KANL3
KAT8 regulatory NSL complex subunit 3

1

3

High-throughput

0.479

High

224383

RERE
Arginine-glutamic acid dipeptide repeats protein

1

11

High-throughput

0.479

High

224385

HDAC6
Protein deacetylase HDAC6

1

10

High-throughput

0.479

High

224387

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

224388

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

224392

TNIK
TRAF2 and NCK-interacting protein kinase

1

10

High-throughput

0.479

High

224393

IKZF3
Zinc finger protein Aiolos

1

7

High-throughput

0.479

High

224394

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

224396

FZR1
Fizzy-related protein homolog

1

19

High-throughput

0.479

High

224398

FAF1
FAS-associated factor 1

1

4

High-throughput

0.479

High

224403

TRAF6
TNF receptor-associated factor 6

1

11

High-throughput

0.479

High

224404

HCFC2
Host cell factor 2

1

7

High-throughput

0.479

High

224299

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

Small-scale

0.458

High

224307

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

224253

NCBP2
Nuclear cap-binding protein subunit 2

1

6

High-throughput

0.445

High

224270

NCBP1
Nuclear cap-binding protein subunit 1

1

1

High-throughput

0.445

High

224275

CDC16
Cell division cycle protein 16 homolog

1

10

High-throughput

0.445

High

224288

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

8

High-throughput

0.445

High

224305

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

10

High-throughput

0.445

High

224319

S2611
Sodium-independent sulfate anion transporter

1

2

High-throughput

0.445

High

224358

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

High-throughput

0.445

High

224361

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.445

High

224362

APC1
Anaphase-promoting complex subunit 1

1

1

High-throughput

0.445

High

224364

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

High-throughput

0.445

High

104900

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

154919

BHE40
Class E basic helix-loop-helix protein 40

1

3

Small-scale

0.437

High

178110

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.437

High

224194

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

224209

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

224221

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

224266

VIGLN
Vigilin

1

20

High-throughput

0.437

High

224314

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

224318

ZCH18
Zinc finger CCCH domain-containing protein 18

1

19

High-throughput

0.437

High

224342

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

224356

ASXL3
Putative Polycomb group protein ASXL3

1

14

High-throughput

0.437

High

224377

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

224380

RN181
E3 ubiquitin-protein ligase RNF181

1

3

High-throughput

0.437

High

224386

ST17A
Serine/threonine-protein kinase 17A

1

4

High-throughput

0.437

High

224395

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

224401

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

224329

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.426

High

224390

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.426

High

224208

ANXA1
Annexin A1

1

3

Small-scale

0.408

High

224219

TOP1
DNA topoisomerase 1

1

2

Small-scale

0.408

High

224243

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.408

High

224303

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.407

High

224214

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

224302

BLTP1
Bridge-like lipid transfer protein family member 1

1

0

High-throughput

0.279

Low

224341

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

224191

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

224202

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

224374

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

224324

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.232

Low

224357

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025