HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ACSL4 (O60488)
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)
Gene: ACSL4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005741 - mitochondrial outer membrane GO:0005783 - endoplasmic reticulum
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 711
+	Hs
		226155 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACSL3_HUMAN (1-711): 0: 724: 65.54
+	Hs
		226653 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACSL1_HUMAN (12-709): 0: 651: 29.01
+	At
		1091814 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		LACS6_ARATH (33-710): 0: 590: 31.92
+	Sc
		477356 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		LCF4_YEAST (46-710): 9.35e-171: 507: 30.39
+	At
		1092426 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		LACS4_ARATH (35-709): 0: 575: 31.50
+	Sc
		477375 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ACS2_YEAST (85-707): 4.38e-144: 438: 15.45
+	At
		82601 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACS_ARATH (32-707): 5.07e-148: 450: 13.70