Protein: NUMB
Protein numb homolog (h-Numb) (Protein S171)

Gene: NUMB
Organism: Homo sapiens
Interactions: 224
UniProt ID: P49757

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005886 - plasma membrane
GO:0005905 - clathrin-coated pit
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889311

LNX1
E3 ubiquitin-protein ligase LNX

4

19

Small-scale

0.906

High

889307

LNX2
Ligand of Numb protein X 2

3

18

Small-scale

0.828

High

421724

A4
Amyloid-beta precursor protein

2

20

High-throughput

0.789

High

889360

NUMBL
Numb-like protein

2

4

High-throughput

0.789

High

889272

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

3

High-throughput

0.743

High

413412

P53
Cellular tumor antigen p53

6

1

Small-scale

0.735

High

889259

MDM2
E3 ubiquitin-protein ligase Mdm2

11

0

Small-scale

0.726

High

889321

AP2M1
AP-2 complex subunit mu

5

6

Small-scale

0.716

High

839716

EPS15
Epidermal growth factor receptor substrate 15

4

20

Small-scale

0.692

High

889324

ITCH
E3 ubiquitin-protein ligase Itchy homolog

3

2

Small-scale

0.680

High

279308

TULP3
Tubby-related protein 3

3

2

High-throughput

0.667

High

857377

NOTC1
Neurogenic locus notch homolog protein 1

3

8

Small-scale

0.651

High

889253

AP2B1
AP-2 complex subunit beta

3

20

Small-scale

0.650

High

362974

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.646

High

889302

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

5

Small-scale

0.646

High

844990

EAA3
Excitatory amino acid transporter 3

3

1

High-throughput

0.643

High

375293

RASK
GTPase KRas

3

18

High-throughput

0.640

High

889354

ALK
ALK tyrosine kinase receptor

3

20

Small-scale

0.640

High

729681

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.635

High

889246

1433G
14-3-3 protein gamma

2

20

High-throughput

0.635

High

889247

1433E
14-3-3 protein epsilon

2

3

High-throughput

0.635

High

889315

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

7

High-throughput

0.628

High

861519

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

2

Small-scale

0.624

High

889306

PALS1
Protein PALS1

1

8

High-throughput

0.621

High

344654

AP2A1
AP-2 complex subunit alpha-1

2

20

Small-scale

0.619

High

159566

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

17

High-throughput

0.618

High

889234

AFAD
Afadin

1

20

High-throughput

0.618

High

889313

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.618

High

483046

CLCA
Clathrin light chain A

2

7

High-throughput

0.611

High

483310

CLCB
Clathrin light chain B

2

7

High-throughput

0.611

High

889254

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

889269

AP1B1
AP-1 complex subunit beta-1

2

20

Small-scale

0.601

High

889268

KPCZ
Protein kinase C zeta type

1

11

Small-scale

0.597

High

603206

KPCA
Protein kinase C alpha type

2

11

Small-scale

0.595

High

889338

DNJC5
DnaJ homolog subfamily C member 5

2

3

High-throughput

0.595

High

220229

FRS3
Fibroblast growth factor receptor substrate 3

2

3

High-throughput

0.594

High

772474

IRS1
Insulin receptor substrate 1

2

5

High-throughput

0.594

High

374468

RASH
GTPase HRas

2

13

High-throughput

0.584

High

540360

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.584

High

582716

EZRI
Ezrin

2

6

High-throughput

0.584

High

630722

RAB4A
Ras-related protein Rab-4A

2

5

High-throughput

0.584

High

889240

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.584

High

889249

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.584

High

889250

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

889303

UN5CL
UNC5C-like protein

2

1

High-throughput

0.574

High

395700

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

889279

RBP1
RalA-binding protein 1

2

3

Small-scale

0.571

High

889347

BMP2K
BMP-2-inducible protein kinase

2

6

Small-scale

0.571

High

466640

GLI1
Zinc finger protein GLI1

1

1

Small-scale

0.561

High

862751

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

15

Small-scale

0.561

High

889238

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

Small-scale

0.561

High

889284

DPYL2
Dihydropyrimidinase-related protein 2

1

2

Small-scale

0.561

High

889267

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

889231

AP2S1
AP-2 complex subunit sigma

2

9

Small-scale

0.552

High

889309

OLIG1
Oligodendrocyte transcription factor 1

2

3

High-throughput

0.542

High

171680

GAK
Cyclin-G-associated kinase

1

10

High-throughput

0.536

High

529346

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.536

High

764543

CTNB1
Catenin beta-1

1

3

Small-scale

0.536

High

889244

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.536

High

889258

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.536

High

889273

PKD2
Polycystin-2

1

1

High-throughput

0.536

High

889286

DREB
Drebrin

1

4

High-throughput

0.536

High

889322

REPS1
RalBP1-associated Eps domain-containing protein 1

1

20

Small-scale

0.536

High

889342

PAAT
ATPase PAAT

1

2

High-throughput

0.536

High

889346

ANLN
Anillin

1

3

High-throughput

0.536

High

889353

KLH21
Kelch-like protein 21

1

5

High-throughput

0.536

High

889281

TERF2
Telomeric repeat-binding factor 2

2

1

High-throughput

0.526

High

809972

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.518

High

532455

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.515

High

292584

RENR
Renin receptor

1

0

High-throughput

0.513

High

536754

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

889256

IGBP1
Immunoglobulin-binding protein 1

1

0

High-throughput

0.513

High

889344

BEX1
Protein BEX1

1

0

High-throughput

0.513

High

889349

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.513

High

436632

KPCB
Protein kinase C beta type

1

11

Small-scale

0.501

High

889263

KPCE
Protein kinase C epsilon type

1

11

Small-scale

0.501

High

889356

FBW1A
F-box/WD repeat-containing protein 1A

1

5

Small-scale

0.500

High

706086

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

866615

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.489

High

889295

SPSB3
SPRY domain-containing SOCS box protein 3

1

6

High-throughput

0.489

High

889312

ZCH10
Zinc finger CCHC domain-containing protein 10

1

2

High-throughput

0.489

High

889316

SPRY4
SPRY domain-containing protein 4

1

3

High-throughput

0.489

High

889348

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.489

High

889357

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

48562

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

126507

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

170017

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

172583

XPO1
Exportin-1

1

5

High-throughput

0.479

High

189457

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

217964

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

225958

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

299111

FLOT1
Flotillin-1

1

5

High-throughput

0.479

High

341002

DIRA3
GTP-binding protein Di-Ras3

1

5

High-throughput

0.479

High

373837

RASN
GTPase NRas

1

18

High-throughput

0.479

High

400487

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

439997

LCK
Tyrosine-protein kinase Lck

1

15

High-throughput

0.479

High

463406

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.479

High

463926

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.479

High

465458

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

466154

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

474548

VIME
Vimentin

1

4

Small-scale

0.479

High

555957

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

561950

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.479

High

580933

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601212

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

603895

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

614667

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

4

High-throughput

0.479

High

630473

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.479

High

631120

RAB5A
Ras-related protein Rab-5A

1

6

High-throughput

0.479

High

642720

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

648460

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

690830

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

710121

EPHA2
Ephrin type-A receptor 2

1

18

High-throughput

0.479

High

710793

EPHB2
Ephrin type-B receptor 2

1

16

High-throughput

0.479

High

715483

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

High-throughput

0.479

High

720160

UFO
Tyrosine-protein kinase receptor UFO

1

16

Small-scale

0.479

High

730453

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

731913

L1CAM
Neural cell adhesion molecule L1

1

2

Small-scale

0.479

High

764280

CTNA1
Catenin alpha-1

1

1

Small-scale

0.479

High

839202

MTOR
Serine/threonine-protein kinase mTOR

1

2

Small-scale

0.479

High

845561

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

861923

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

872075

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.479

High

889226

VASP
Vasodilator-stimulated phosphoprotein

1

5

High-throughput

0.479

High

889227

FXR1
RNA-binding protein FXR1

1

2

High-throughput

0.479

High

889228

RAB5C
Ras-related protein Rab-5C

1

6

High-throughput

0.479

High

889229

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.479

High

889230

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

889232

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.479

High

889233

EPHA4
Ephrin type-A receptor 4

1

19

High-throughput

0.479

High

889236

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.479

High

889239

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

889242

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

889243

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

889248

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

889251

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

889252

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

889255

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.479

High

889257

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

889261

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.479

High

889262

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

889264

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

889266

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

889270

STX4
Syntaxin-4

1

4

High-throughput

0.479

High

889275

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

889277

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

889278

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.479

High

889280

EPHA7
Ephrin type-A receptor 7

1

16

High-throughput

0.479

High

889282

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

889283

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.479

High

889285

OCLN
Occludin

1

3

High-throughput

0.479

High

889288

AAK1
AP2-associated protein kinase 1

1

8

High-throughput

0.479

High

889292

RNF43
E3 ubiquitin-protein ligase RNF43

1

3

High-throughput

0.479

High

889293

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

889296

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

889297

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

889299

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

3

High-throughput

0.479

High

889304

RPTOR
Regulatory-associated protein of mTOR

1

4

Small-scale

0.479

High

889305

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

889310

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.479

High

889314

SMAP2
Stromal membrane-associated protein 2

1

7

High-throughput

0.479

High

889317

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

889319

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

889326

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

889327

FMNL2
Formin-like protein 2

1

1

High-throughput

0.479

High

889329

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

889330

LST8
Target of rapamycin complex subunit LST8

1

3

Small-scale

0.479

High

889331

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

889335

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

889336

WWTR1
WW domain-containing transcription regulator protein 1

1

4

High-throughput

0.479

High

889337

TRPV6
Transient receptor potential cation channel subfamily V member 6

1

2

Small-scale

0.479

High

889339

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

889340

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

889343

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

889345

E41LA
Band 4.1-like protein 4A

1

5

High-throughput

0.479

High

889352

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

889355

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

49297

SHOT1
Shootin-1

1

0

Small-scale

0.458

High

889328

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

889334

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

889341

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

323685

AP2A2
AP-2 complex subunit alpha-2

1

20

Small-scale

0.445

High

616730

SDC1
Syndecan-1

1

1

High-throughput

0.445

High

871904

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

3

High-throughput

0.445

High

877644

SL9A3
Sodium/hydrogen exchanger 3

1

1

High-throughput

0.445

High

889235

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.445

High

889260

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

889287

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

1

High-throughput

0.445

High

889333

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

889351

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

19

Small-scale

0.445

High

889358

SNX9
Sorting nexin-9

1

2

High-throughput

0.445

High

889325

EAF1
ELL-associated factor 1

1

1

High-throughput

0.439

High

179845

BET1
BET1 homolog

1

4

High-throughput

0.437

High

181694

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.437

High

327197

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

405905

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

889241

RAB2A
Ras-related protein Rab-2A

1

5

High-throughput

0.437

High

889245

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.437

High

889276

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.437

High

889298

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.437

High

889300

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.437

High

889308

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.437

High

889318

ESR2
Estrogen receptor beta

1

10

High-throughput

0.437

High

889320

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.437

High

889332

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.437

High

765254

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.407

High

889290

BTBD8
BTB/POZ domain-containing protein 8

1

8

High-throughput

0.407

High

889294

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.407

High

889323

STALP
AMSH-like protease

2

0

High-throughput

0.328

High

889237

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.279

Low

889265

COAA1

1

0

High-throughput

0.279

Low

889274

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.279

Low

889359

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

889271

PDZ1I
PDZK1-interacting protein 1

1

0

High-throughput

0.251

Low

889289

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.251

Low

139828

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

317616

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.249

Low

694925

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767695

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

880483

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

889291

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

889301

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

889350

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

261941

RNH1
Ribonuclease H1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025