Protein: NUMBL
Numb-like protein (Numb-related protein) (Numb-R)

Gene: NUMBL
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q9Y6R0

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0007399 - nervous system development
GO:0007409 - axonogenesis
GO:0019221 - cytokine-mediated signaling pathway
GO:0019538 - protein metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889360

NUMB
Protein numb homolog

2

4

High-throughput

0.789

High

730404

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.716

High

967088

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

1049959

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

1491436

TRAF6
TNF receptor-associated factor 6

4

12

Small-scale

0.692

High

845172

EAA3
Excitatory amino acid transporter 3

4

1

High-throughput

0.687

High

1452649

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

2

4

Small-scale

0.642

High

972190

1433E
14-3-3 protein epsilon

2

3

High-throughput

0.635

High

1358893

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

7

High-throughput

0.628

High

159941

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

16

High-throughput

0.618

High

1348600

LNX1
E3 ubiquitin-protein ligase LNX

1

18

Small-scale

0.618

High

990933

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1245020

SPSB3
SPRY domain-containing SOCS box protein 3

3

9

High-throughput

0.597

High

364107

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.595

High

136738

TRAF5
TNF receptor-associated factor 5

2

10

Small-scale

0.586

High

376165

RASK
GTPase KRas

2

19

High-throughput

0.584

High

583050

EZRI
Ezrin

2

7

High-throughput

0.584

High

976712

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.584

High

1451156

RFOX1
RNA binding protein fox-1 homolog 1

1

2

High-throughput

0.582

High

1308424

UN5CL
UNC5C-like protein

2

1

High-throughput

0.574

High

397350

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

1491271

GRIP1
Glutamate receptor-interacting protein 1

1

17

Small-scale

0.555

High

691591

1433T
14-3-3 protein theta

1

20

High-throughput

0.554

High

927642

ATX1
Ataxin-1

1

1

High-throughput

0.541

High

1436419

PAAT
ATPase PAAT

1

3

High-throughput

0.536

High

374319

RASN
GTPase NRas

2

19

High-throughput

0.533

High

1462025

ALK
ALK tyrosine kinase receptor

2

20

High-throughput

0.533

High

324068

CSTN1
Calsyntenin-1

1

4

High-throughput

0.515

High

699913

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.515

High

1025533

CDK5
Cyclin-dependent kinase 5

1

4

High-throughput

0.515

High

1050588

UBE3A
Ubiquitin-protein ligase E3A

1

3

Small-scale

0.501

High

1452906

GTSE1
G2 and S phase-expressed protein 1

1

3

High-throughput

0.489

High

1459767

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.489

High

155045

BHE40
Class E basic helix-loop-helix protein 40

1

1

High-throughput

0.481

High

1109695

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

11

High-throughput

0.481

High

1307826

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

6

High-throughput

0.481

High

173628

XPO1
Exportin-1

1

4

High-throughput

0.479

High

299454

FLOT1
Flotillin-1

1

5

High-throughput

0.479

High

375060

RASH
GTPase HRas

1

14

High-throughput

0.479

High

440265

LCK
Tyrosine-protein kinase Lck

1

16

High-throughput

0.479

High

459826

PROF1
Profilin-1

1

3

High-throughput

0.479

High

463876

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.479

High

541790

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

556453

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

604302

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

631053

RAB4A
Ras-related protein Rab-4A

1

5

High-throughput

0.479

High

714564

PML
Protein PML

1

2

High-throughput

0.479

High

715874

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

896679

VASP
Vasodilator-stimulated phosphoprotein

1

6

High-throughput

0.479

High

942995

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.479

High

953220

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.479

High

975358

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

989183

AP2B1
AP-2 complex subunit beta

1

20

High-throughput

0.479

High

1004255

CXAR
Coxsackievirus and adenovirus receptor

1

4

High-throughput

0.479

High

1034212

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.479

High

1041401

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1147476

EPHA7
Ephrin type-A receptor 7

1

16

High-throughput

0.479

High

1356351

SMAP2
Stromal membrane-associated protein 2

1

8

High-throughput

0.479

High

1459511

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1491851

NEMO
NF-kappa-B essential modulator

1

7

Small-scale

0.479

High

555793

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.460

High

681567

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.460

High

1393890

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1449641

CBLN4
Cerebellin-4

1

4

High-throughput

0.445

High

1491762

SNX9
Sorting nexin-9

1

3

High-throughput

0.445

High

1435165

ESRP2
Epithelial splicing regulatory protein 2

1

1

High-throughput

0.439

High

1461110

GPTC8
G patch domain-containing protein 8

1

1

High-throughput

0.439

High

1491749

MAGD1
Melanoma-associated antigen D1

1

3

High-throughput

0.439

High

106944

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

181750

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.437

High

189965

STX7
Syntaxin-7

1

5

High-throughput

0.437

High

219044

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.437

High

226291

STX6
Syntaxin-6

1

5

High-throughput

0.437

High

279556

TULP3
Tubby-related protein 3

1

2

High-throughput

0.437

High

327526

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

341188

DIRA3
GTP-binding protein Di-Ras3

1

5

High-throughput

0.437

High

412911

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

464094

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.437

High

465703

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.437

High

483287

CLCA
Clathrin light chain A

1

9

High-throughput

0.437

High

483425

CLCB
Clathrin light chain B

1

9

High-throughput

0.437

High

562529

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.437

High

601525

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.437

High

614749

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

4

High-throughput

0.437

High

643173

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

648759

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.437

High

845885

MUC18
Cell surface glycoprotein MUC18

1

6

High-throughput

0.437

High

902178

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.437

High

905356

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.437

High

945131

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.437

High

1034393

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.437

High

1145209

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.437

High

1159933

OCLN
Occludin

1

3

High-throughput

0.437

High

1233628

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

1289758

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.437

High

1323069

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.437

High

1333390

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.437

High

1363917

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.437

High

1382027

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.437

High

1418563

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1433029

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.437

High

1433610

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.437

High

1438283

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.437

High

1450992

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

6

High-throughput

0.437

High

1462802

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.437

High

935376

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

877733

SL9A3
Sodium/hydrogen exchanger 3

1

1

High-throughput

0.407

High

922627

AP2S1
AP-2 complex subunit sigma

1

11

High-throughput

0.407

High

1168626

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

1

High-throughput

0.407

High

1220511

BTBD8
BTB/POZ domain-containing protein 8

1

8

High-throughput

0.407

High

519683

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.251

Low

821241

TPO
Thrombopoietin

1

0

High-throughput

0.251

Low

1250151

TMC5
Transmembrane channel-like protein 5

1

0

High-throughput

0.251

Low

279010

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.249

Low

1400884

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

1491256

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025