HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SYN1 (P17600)
Synapsin-1 (Brain protein 4.1) (Synapsin I)
Gene: SYN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11431533
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005794 - Golgi apparatus GO:0014069 - postsynaptic density GO:0019901 - protein kinase binding GO:0098793 - presynapse
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 705
+	Hs
		226120 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC31A_HUMAN (337-705): 2.53e-26: 117: 14.71
+	Hs
		228683 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PTN23_HUMAN (336-691): 3.68e-20: 98.1: 16.75
+	Hs
		226957 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24C_HUMAN (460-704): 1.13e-10: 67.3: 16.42
+	Hs
		228928 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OGFR_HUMAN (403-616): 2.13e-10: 66.1: 19.56
+	Hs
		228101 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KMT2C_HUMAN (348-705): 2.49e-09: 63: 10.70
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (370-701): 2.77e-09: 63: 13.21
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (346-690): 8.34e-12: 71.1: 11.71
+	Hs
		302333 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		SC31A_HUMAN (337-705): 2.53e-26: 117: 14.71
+	Hs
		312519 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		SMCA4_HUMAN (369-705): 1.59e-23: 108: 15.92
+	Rn
		94376 HOIL1_RAT (12-448): 8.73e-66: 221: 17.05		F1M9G7_RAT (381-685): 1.16e-20: 100: 14.75
+	Hs
		312672 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		OGFR_HUMAN (403-616): 2.13e-10: 66.1: 19.56
+	Hs
		302245 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SC31A_HUMAN (337-705): 2.53e-26: 117: 14.71
+	Hs
		476367 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PTN23_HUMAN (336-691): 3.68e-20: 98.1: 16.75
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (375-677): 1.5e-14: 80: 15.05
+	At
		1092229 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24C_ARATH (373-622): 4.57e-10: 65.3: 12.08
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (393-700): 6.47e-09: 61.5: 12.99