HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSB1 (P20618)
Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain)
Gene: PSMB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 241
+	Hs
		226855 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB3_HUMAN (31-241): 3.45e-82: 246: 23.94
+	Hs
		156176 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA7_HUMAN (17-241): 8.16e-79: 238: 13.54
+	Hs
		227023 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA6_HUMAN (17-240): 4.32e-77: 234: 14.91
+	Hs
		226567 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA4_HUMAN (8-240): 1.49e-75: 231: 17.72
+	Hs
		226590 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA5_HUMAN (16-240): 7.6e-75: 228: 16.67
+	Hs
		226593 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB5_HUMAN (9-230): 4.76e-73: 224: 20.27
+	Hs
		226592 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB6_HUMAN (34-236): 8.15e-56: 180: 21.68
+	Hs
		594583 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PSB1_HUMAN (1-241): 8.65e-85: 253: 100.00
+	Hs
		893742 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		PSA6_HUMAN (17-240): 4.32e-77: 234: 14.91
+	Hs
		226856 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB2_HUMAN (40-233): 2.78e-09: 57: 24.62
+	Hs
		474931 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA4_HUMAN (8-240): 1.49e-75: 231: 17.72
+	Zm
		28714 A0A1D6JU68_MAIZE (202-460): 6.3e-59: 205: 22.18		C0PFF5_MAIZE (39-233): 6.06e-55: 177: 27.55
+	Hs
		475330 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB1_HUMAN (1-241): 8.65e-85: 253: 100.00
+	Zm
		35351 Q42415_MAIZE (1-153): 8.84e-50: 179: 20.13		A0A1D6LKR2_MAIZE (37-240): 1.06e-61: 195: 23.08
+	Hs
		156205 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA7_HUMAN (17-241): 8.16e-79: 238: 13.54
+	Hs
		475547 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA6_HUMAN (17-240): 4.32e-77: 234: 14.91
+	Hs
		475369 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA5_HUMAN (16-240): 7.6e-75: 228: 16.67
+	Hs
		475371 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB5_HUMAN (9-230): 4.76e-73: 224: 20.27
+	Hs
		475370 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB6_HUMAN (34-236): 8.15e-56: 180: 21.68
+	Hs
		475487 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB2_HUMAN (40-233): 2.78e-09: 57: 24.62