HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: THIL (P24752)
Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)
Gene: ACAT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	35256949, 35509820
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum GO:0019899 - enzyme binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 427
+	Hs
		228566 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		THIC_HUMAN (42-426): 7.37e-166: 473: 42.93
+	Hs
		226761 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		THIM_HUMAN (37-425): 3.26e-163: 466: 40.00
+	Hs
		226981 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ECHB_HUMAN (14-425): 4.34e-155: 448: 30.62
+	Sc
		477326 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ERG10_YEAST (40-427): 2.69e-163: 466: 48.49
+	At
		1091829 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACCT2_ARATH (33-427): 8.05e-167: 476: 50.75
+	At
		1091700 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		THIK2_ARATH (3-426): 1.87e-159: 459: 30.59
+	Hs
		475530 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ECHB_HUMAN (14-425): 4.34e-155: 448: 30.62