HitPredict

Interactor 1: SGTA (O43765)
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP)
Gene: SGTA

Interactor 2: SGTB (Q96EQ0)
Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2)
Gene: SGTB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.836

Property	Details
Experiments	32296183, unassigned1304, unassigned3799
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SGTA_dimer~SGTA_dimer, TPR_1~TPR_1, TPR_1~TPR_11, TPR_1~TPR_8, TPR_11~TPR_8
Common GO terms	GO:0006620 - post-translational protein targeting to endoplasmic reticulum membrane GO:0016020 - membrane GO:0060090 - molecular adaptor activity GO:0072380 - TRC complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 313 Hs			1 304
+	Hs
		226630 SGTA_HUMAN (1-313): 4.33e-68: 216: 100.00		SGTA_HUMAN (1-303): 1.75e-59: 194: 57.56
+	Rn
		267283 SGTA_RAT (1-313): 1.02e-65: 210: 88.54		SGTA_RAT (1-303): 1.02e-57: 189: 56.55
+	Hs
		1389486 SGTB_HUMAN (1-311): 1.35e-54: 181: 57.24		SGTB_HUMAN (1-304): 1.7e-67: 214: 100.00
+	Mm
		1296828 SGTA_MOUSE (1-313): 1.42e-63: 205: 87.62		SGTA_MOUSE (1-303): 1.71e-56: 186: 56.37
+	Hs
		226714 SGTA_HUMAN (1-313): 4.33e-68: 216: 100.00		STIP1_HUMAN (36-258): 3.56e-22: 98.4: 18.70
+	Sc
		1084322 SGT2_YEAST (2-298): 5.31e-38: 139: 28.45		SGT2_YEAST (1-269): 2.2e-43: 153: 28.93
+	Hs
		1462264 CHIP_HUMAN (66-229): 1.8e-41: 147: 27.22		CHIP_HUMAN (63-222): 3.31e-40: 143: 26.67
+	Ce
		1170379 Q21746_CAEEL (2-298): 3.25e-38: 139: 40.07		Q21746_CAEEL (2-290): 6.54e-42: 149: 36.76
+	Mm
		1490151 CHIP_MOUSE (66-229): 4.35e-40: 143: 26.04		CHIP_MOUSE (63-219): 1.31e-39: 142: 25.93
+	Hs
		916630 PPP5_HUMAN (66-268): 8.29e-37: 139: 24.63		PPP5_HUMAN (64-239): 2.72e-39: 145: 24.86
+	Dm
		1475644 Q9VH81_DROME (65-239): 2.37e-41: 152: 28.81		Q9VJD4_DROME (2-295): 4.73e-35: 131: 25.46
+	Dm
		1478347 Q9VJD4_DROME (2-289): 7.51e-43: 151: 28.40		Q9VJD4_DROME (2-295): 4.73e-35: 131: 25.46
+	Ps
		1444869 TOC64_PEA (45-207): 8.8e-37: 140: 31.29		TOC64_PEA (48-201): 4.86e-36: 138: 31.82
+	Hs
		718525 PPP5_HUMAN (66-268): 8.29e-37: 139: 24.63		CDC27_HUMAN (8-239): 4.96e-27: 113: 15.52
+	Hs
		731115 PPP5_HUMAN (66-268): 8.29e-37: 139: 24.63		STIP1_HUMAN (36-258): 3.56e-22: 98.4: 18.70
+	Dm
		1475708 Q9VH81_DROME (65-239): 2.37e-41: 152: 28.81		Q9VPN5_DROME (43-249): 7.27e-18: 85.3: 18.98
+	Dm
		1478365 Q9VJD4_DROME (2-289): 7.51e-43: 151: 28.40		Q9VPN5_DROME (43-249): 7.27e-18: 85.3: 18.98
+	Hs
		185549 PPP5_HUMAN (66-268): 8.29e-37: 139: 24.63		OGT1_HUMAN (79-288): 3.02e-21: 96.1: 13.33
+	Sc
		585659 SGT2_YEAST (2-298): 5.31e-38: 139: 28.45		STI1_YEAST (48-210): 1.27e-17: 84.8: 23.53