HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSB2 (P49721)
Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I)
Gene: PSMB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 201
+	Hs
		226593 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB5_HUMAN (2-197): 1.96e-66: 206: 17.86
+	Hs
		226567 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA4_HUMAN (3-198): 5.76e-65: 202: 17.73
+	Hs
		228452 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB7_HUMAN (3-199): 1.32e-64: 202: 19.80
+	Hs
		226565 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA2_HUMAN (4-197): 1.04e-64: 201: 17.86
+	Hs
		226503 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB1_HUMAN (3-198): 2.07e-57: 182: 23.42
+	Hs
		226730 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB10_HUMAN (3-199): 1.9e-45: 153: 21.83
+	Hs
		226592 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB6_HUMAN (3-188): 2.95e-44: 148: 17.74
+	Hs
		594583 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PSB1_HUMAN (3-198): 2.07e-57: 182: 23.42
+	Zm
		28714 A0A1D6JU68_MAIZE (202-460): 6.3e-59: 205: 22.18		C0PFF5_MAIZE (1-190): 5.73e-81: 241: 44.21
+	Sc
		477128 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PSB4_YEAST (1-193): 1.25e-78: 235: 44.85
+	Hs
		474931 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA4_HUMAN (3-198): 5.76e-65: 202: 17.73
+	Hs
		474930 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA2_HUMAN (4-197): 1.04e-64: 201: 17.86
+	Zm
		35351 Q42415_MAIZE (1-153): 8.84e-50: 179: 20.13		A0A1D6LKR2_MAIZE (3-190): 9.29e-47: 155: 17.71
+	Hs
		475371 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB5_HUMAN (2-197): 1.96e-66: 206: 17.86
+	At
		188696 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA2A_ARATH (2-197): 1.83e-66: 205: 18.09
+	Hs
		476251 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB7_HUMAN (3-199): 1.32e-64: 202: 19.80
+	Hs
		475359 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA2_HUMAN (4-197): 1.04e-64: 201: 17.86
+	Hs
		475487 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB2_HUMAN (1-201): 5.46e-65: 200: 100.00
+	Hs
		475330 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB1_HUMAN (3-198): 2.07e-57: 182: 23.42
+	Hs
		475370 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB6_HUMAN (3-188): 2.95e-44: 148: 17.74