HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NEK5 (Q6P3R8)
Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5)
Gene: NEK5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 708
+	Hs
		226582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK3_HUMAN (1-649): 1.41e-141: 434: 16.40
+	Hs
		227863 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK2_HUMAN (1-688): 7.86e-141: 433: 16.05
+	Hs
		228960 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6B2_HUMAN (4-413): 1.83e-130: 396: 19.76
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (1-328): 3.45e-130: 395: 23.65
+	Hs
		226457 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KAPCA_HUMAN (1-313): 1.46e-129: 389: 25.71
+	Hs
		227317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK4_HUMAN (2-496): 2.4e-125: 383: 24.60
+	Hs
		226534 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KAPCB_HUMAN (1-310): 5.93e-127: 382: 24.37
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (1-276): 7.21e-114: 353: 27.92
+	Hs
		228141 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK9_HUMAN (4-259): 2.54e-57: 212: 40.70
+	Hs
		226921 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK2_HUMAN (2-263): 1.9e-54: 195: 40.59
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (1-328): 3.45e-130: 395: 23.65
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (1-276): 7.21e-114: 353: 27.92
+	Hs
		228149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK7_HUMAN (1-253): 7.04e-50: 178: 36.68
+	Hs
		475012 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STK4_HUMAN (2-496): 2.4e-125: 383: 24.60
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (1-276): 7.21e-114: 353: 27.92
+	Hs
		475345 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KS6B1_HUMAN (2-426): 8.86e-129: 393: 21.32
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (1-276): 7.21e-114: 353: 27.92
+	Hs
		1168524 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		NEK9_HUMAN (4-259): 2.54e-57: 212: 40.70
+	Hs
		475987 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NEK8_HUMAN (1-258): 3.48e-73: 252: 46.90
+	Hs
		476090 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NEK9_HUMAN (4-259): 2.54e-57: 212: 40.70