HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: WDFY1 (Q8IWB7)
WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17)
Gene: WDFY1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 410
+	Hs
		228555 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KTNB1_HUMAN (186-409): 1.49e-35: 140: 14.67
+	Hs
		228612 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL1R_HUMAN (227-408): 3.24e-19: 91.4: 14.84
+	Hs
		229023 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBW1B_HUMAN (16-184): 9.32e-18: 87.2: 15.82
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (1-92): 3.86e-17: 84: 15.15
+	Hs
		152845 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		APAF_HUMAN (17-106): 1.4e-15: 81.2: 13.54
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (275-408): 7.94e-16: 81: 9.63
+	Hs
		159798 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HGS_HUMAN (276-351): 5.58e-15: 79: 42.11
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (1-96): 7.71e-15: 77.1: 12.87
+	Hs
		229098 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBW1A_HUMAN (15-146): 2.66e-12: 70.2: 18.98
+	Hs
		227540 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TAF5_HUMAN (12-88): 2.95e-10: 64.2: 14.14
+	Hs
		227122 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RACK1_HUMAN (186-410): 8.67e-10: 61.4: 19.13
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (352-408): 4.12e-09: 60.2: 12.28
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (1-92): 3.86e-17: 84: 15.15
+	Hs
		1356385 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBW1B_HUMAN (16-184): 9.32e-18: 87.2: 15.82
+	Hs
		1377165 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBW1A_HUMAN (15-146): 2.66e-12: 70.2: 18.98
+	Hs
		160178 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		HGS_HUMAN (276-351): 5.58e-15: 79: 42.11
+	Hs
		3258 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		A0A0S2Z4Q4_HUMAN (276-351): 6.46e-15: 78.6: 42.11
+	Sc
		477393 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		COPA_YEAST (1-383): 5.69e-22: 100: 12.44
+	Hs
		159860 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HGS_HUMAN (276-351): 5.58e-15: 79: 42.11
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (1-96): 7.71e-15: 77.1: 12.87