HitPredict

Interactor 1: NUAK1 (O60285)
NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)
Gene: NUAK1

Interactor 2: USP9X (Q93008)
Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)
Gene: USP9X

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	18254724, 32707033, 24785407, 16306228
Identification Methods	affinity chromatography technology, enzymatic study, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 661 Hs			1 2554
+	Rn
		88538 D3ZQN8_RAT (1-661): 0: 552: 90.35		D3ZC84_RAT (1-2554): 0: 3644: 98.40
+	Hs
		1273704 MARK4_HUMAN (4-655): 1.51e-155: 468: 27.16		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1273723 NUAK2_HUMAN (1-661): 2.59e-148: 445: 49.92		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		871452 AAPK2_HUMAN (43-323): 6.43e-69: 236: 44.33		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Dm
		90533 E1JGN0_DROME (8-658): 2.11e-147: 458: 23.29		FAF_DROME (15-2492): 0: 2803: 47.31
+	Hs
		1273797 MARK4_HUMAN (4-655): 1.51e-155: 468: 27.16		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Mm
		1113466 KCC2D_MOUSE (50-557): 3.32e-142: 425: 23.55		UBP48_MOUSE (1473-2106): 9.99e-103: 359: 19.73
+	Hs
		1273864 NUAK2_HUMAN (1-661): 2.59e-148: 445: 49.92		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Sc
		419924 SNF1_YEAST (55-509): 1.88e-132: 405: 29.98		UBP8_YEAST (1555-1921): 2.04e-20: 99.4: 25.13