Protein: MK04
Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK)

Gene: MK04, MAPK4
Organism: Homo sapiens
Interactions: 68
UniProt ID: P31152

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

724694

MAPK5
MAP kinase-activated protein kinase 5

4

20

Small-scale

0.905

High

468107

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.802

High

461186

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

724663

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.756

High

692657

CALL3
Calmodulin-like protein 3

1

11

High-throughput

0.698

High

187297

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

4

High-throughput

0.691

High

287661

KS6A5
Ribosomal protein S6 kinase alpha-5

1

20

High-throughput

0.691

High

290298

KS6A4
Ribosomal protein S6 kinase alpha-4

1

20

High-throughput

0.691

High

335306

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

20

High-throughput

0.691

High

724672

IRAK1
Interleukin-1 receptor-associated kinase 1

1

14

High-throughput

0.691

High

724674

RD23B
UV excision repair protein RAD23 homolog B

1

9

High-throughput

0.691

High

724679

PAK1
Serine/threonine-protein kinase PAK 1

1

9

High-throughput

0.691

High

724680

PAK2
Serine/threonine-protein kinase PAK 2

1

8

High-throughput

0.691

High

724681

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

15

High-throughput

0.691

High

724682

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

14

High-throughput

0.691

High

724683

CDC37
Hsp90 co-chaperone Cdc37

1

8

High-throughput

0.691

High

724684

MK06
Mitogen-activated protein kinase 6

1

17

High-throughput

0.691

High

724700

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

19

High-throughput

0.691

High

724705

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

High-throughput

0.691

High

229967

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

3

High-throughput

0.628

High

724677

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

2

12

High-throughput

0.628

High

724693

RB6I2
ELKS/Rab6-interacting/CAST family member 1

2

14

High-throughput

0.628

High

724701

SAHH3
Adenosylhomocysteinase 3

2

3

High-throughput

0.628

High

724695

DJC10
DnaJ homolog subfamily C member 10

1

7

High-throughput

0.618

High

724678

DUSP2
Dual specificity protein phosphatase 2

1

20

High-throughput

0.618

High

724691

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

3

1

High-throughput

0.616

High

724708

TECR
Very-long-chain enoyl-CoA reductase

2

0

High-throughput

0.602

High

724692

PKHH3
Pleckstrin homology domain-containing family H member 3

2

3

High-throughput

0.574

High

724666

CRK
Adapter molecule crk

1

4

High-throughput

0.541

High

165272

PSA7
Proteasome subunit alpha type-7

1

5

High-throughput

0.536

High

420388

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

7

High-throughput

0.536

High

536589

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.536

High

610540

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.536

High

722892

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

6

High-throughput

0.536

High

724665

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

724667

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

724668

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

724669

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

724670

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

724671

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

3

High-throughput

0.536

High

724673

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

4

High-throughput

0.536

High

724676

PRKDC
DNA-dependent protein kinase catalytic subunit

1

2

High-throughput

0.536

High

724686

HKDC1
Hexokinase HKDC1

1

2

High-throughput

0.536

High

724687

ATD3B
ATPase family AAA domain-containing protein 3B

1

13

High-throughput

0.536

High

724688

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

10

High-throughput

0.536

High

724690

SFXN4
Sideroflexin-4

1

2

High-throughput

0.536

High

724699

GCN1
Stalled ribosome sensor GCN1

1

11

High-throughput

0.536

High

724704

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.536

High

724706

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

724707

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.536

High

724710

DIC
Mitochondrial dicarboxylate carrier

1

11

High-throughput

0.536

High

724712

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

High-throughput

0.536

High

162089

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

High-throughput

0.513

High

724685

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.513

High

724689

ASTL
Astacin-like metalloendopeptidase

1

0

High-throughput

0.513

High

50498

HACL2
2-hydroxyacyl-CoA lyase 2

1

5

High-throughput

0.489

High

724696

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

14

High-throughput

0.489

High

724698

FACR1
Fatty acyl-CoA reductase 1

1

1

High-throughput

0.489

High

724709

HPBP1
Hsp70-binding protein 1

1

3

High-throughput

0.489

High

724713

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.489

High

339434

ACSL3
Fatty acid CoA ligase Acsl3

1

3

High-throughput

0.479

High

724664

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

724675

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.479

High

724711

FZR1
Fizzy-related protein homolog

1

9

High-throughput

0.479

High

724702

SFXN2
Sideroflexin-2

1

2

High-throughput

0.437

High

567804

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.279

Low

724697

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

724703

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025