Protein: ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)

Gene: ASH2L
Organism: Homo sapiens
Interactions: 215
UniProt ID: Q9UBL3

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

975339

KMT2A
Histone-lysine N-methyltransferase 2A

17

20

Small-scale

0.987

High

152695

KMT2D
Histone-lysine N-methyltransferase 2D

16

20

Small-scale

0.985

High

165730

SET1A
Histone-lysine N-methyltransferase SETD1A

15

20

Small-scale

0.985

High

1243848

KMT2C
Histone-lysine N-methyltransferase 2C

13

20

Small-scale

0.982

High

1354087

SET1B
Histone-lysine N-methyltransferase SETD1B

10

20

Small-scale

0.978

High

1354085

KMT2B
Histone-lysine N-methyltransferase 2B

10

20

Small-scale

0.976

High

1354080

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

3

15

Small-scale

0.834

High

1336302

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

20

Small-scale

0.834

High

1070799

RBBP5
Retinoblastoma-binding protein 5

29

18

Small-scale

0.769

High

903577

WDR5
WD repeat-containing protein 5

27

14

Small-scale

0.768

High

1318614

DPY30
Protein dpy-30 homolog

20

5

Small-scale

0.767

High

1349840

CXXC1
CXXC-type zinc finger protein 1

15

14

Small-scale

0.762

High

1057800

NCOA6
Nuclear receptor coactivator 6

11

12

Small-scale

0.758

High

183170

KDM6A
Lysine-specific demethylase 6A

11

7

Small-scale

0.754

High

848312

HCFC1
Host cell factor 1

9

7

Small-scale

0.753

High

1173262

PAXI1
PAX-interacting protein 1

8

9

Small-scale

0.751

High

1354094

HCFC2
Host cell factor 2

8

8

Small-scale

0.750

High

123061

MEN1
Menin

7

2

Small-scale

0.741

High

1166731

WDR82
WD repeat-containing protein 82

6

20

Small-scale

0.732

High

175277

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

6

4

Small-scale

0.724

High

1244249

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

4

7

Small-scale

0.694

High

387656

P53
Cellular tumor antigen p53

3

8

Small-scale

0.686

High

370623

ESR1
Estrogen receptor

4

20

Small-scale

0.683

High

1312205

PAGR1
PAXIP1-associated glutamate-rich protein 1

4

0

Small-scale

0.661

High

304377

UBR5
E3 ubiquitin-protein ligase UBR5

3

12

Small-scale

0.656

High

1294519

BOD1
Biorientation of chromosomes in cell division protein 1

3

1

Small-scale

0.656

High

1086338

H31T
Histone H3.1t

3

13

Small-scale

0.655

High

1224162

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

20

Small-scale

0.647

High

931915

CSK2B
Casein kinase II subunit beta

3

0

Small-scale

0.628

High

295349

RECQ4
ATP-dependent DNA helicase Q4

1

13

High-throughput

0.618

High

1080434

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.618

High

1170094

SRCAP
Helicase SRCAP

1

15

High-throughput

0.618

High

1350239

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

20

Small-scale

0.618

High

150110

UTY
Histone demethylase UTY

2

7

Small-scale

0.611

High

487812

ANDR
Androgen receptor

2

20

Small-scale

0.611

High

587039

CSK22
Casein kinase II subunit alpha'

2

4

Small-scale

0.611

High

1190883

EMSY
BRCA2-interacting transcriptional repressor EMSY

2

12

Small-scale

0.611

High

717394

CTNB1
Catenin beta-1

2

8

Small-scale

0.602

High

999165

EP300
Histone acetyltransferase p300

1

12

Small-scale

0.597

High

1012439

Q0VDC6
peptidylprolyl isomerase

1

10

High-throughput

0.594

High

740613

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.594

High

749922

BRCA1
Breast cancer type 1 susceptibility protein

2

16

High-throughput

0.586

High

900302

RL37A
Large ribosomal subunit protein eL43

2

0

High-throughput

0.585

High

607843

USF1
Upstream stimulatory factor 1

2

14

Small-scale

0.584

High

818559

SOX2
Transcription factor SOX-2

2

18

Small-scale

0.584

High

853503

IMA1
Importin subunit alpha-1

2

4

Small-scale

0.584

High

918076

H4
Histone H4

2

7

High-throughput

0.584

High

1050830

FHL2
Four and a half LIM domains protein 2

2

7

Small-scale

0.584

High

1077612

ELF2
ETS-related transcription factor Elf-2

2

13

High-throughput

0.584

High

1281450

FBXW7
F-box/WD repeat-containing protein 7

2

18

Small-scale

0.584

High

1345371

MBIP1
MAP3K12-binding inhibitory protein 1

2

3

High-throughput

0.584

High

624524

CCNC
Cyclin-C

2

0

High-throughput

0.580

High

881716

NDK5
Nucleoside diphosphate kinase homolog 5

2

3

High-throughput

0.558

High

1223683

MICU2
Calcium uptake protein 2, mitochondrial

2

1

High-throughput

0.558

High

1331843

ZN335
Zinc finger protein 335

1

2

Small-scale

0.554

High

1251554

CEP76
Centrosomal protein of 76 kDa

2

1

High-throughput

0.553

High

1172100

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

1071518

ANKR1
Ankyrin repeat domain-containing protein 1

1

6

High-throughput

0.541

High

1185002

CSN6
COP9 signalosome complex subunit 6

1

5

High-throughput

0.541

High

1239655

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

3

High-throughput

0.541

High

1327930

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

11

High-throughput

0.541

High

1354082

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

4

High-throughput

0.541

High

1310379

PYGO2
Pygopus homolog 2

1

0

Small-scale

0.537

High

211268

BUB3
Mitotic checkpoint protein BUB3

1

16

High-throughput

0.536

High

215700

AKAP8
A-kinase anchor protein 8

1

2

Small-scale

0.536

High

470190

H2AZ
Histone H2A.Z

1

5

High-throughput

0.536

High

565056

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.536

High

801441

KI67
Proliferation marker protein Ki-67

1

10

High-throughput

0.536

High

830495

KC1E
Casein kinase I isoform epsilon

1

4

High-throughput

0.536

High

899389

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.536

High

919293

RAN
GTP-binding nuclear protein Ran

1

4

High-throughput

0.536

High

1066819

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.536

High

1087453

H2B2E
Histone H2B type 2-E

1

10

High-throughput

0.536

High

1230557

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

Small-scale

0.536

High

1268603

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

14

High-throughput

0.536

High

1292273

AURKB
Aurora kinase B

1

9

High-throughput

0.536

High

1318655

FOXQ1
Forkhead box protein Q1

1

13

High-throughput

0.536

High

1328691

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

1336360

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.536

High

1354089

KDM2A
Lysine-specific demethylase 2A

1

5

High-throughput

0.536

High

1139970

SPRY7
SPRY domain-containing protein 7

1

0

Small-scale

0.517

High

871813

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.515

High

1158337

CDC73
Parafibromin

1

0

Small-scale

0.513

High

171460

SMAD9
Mothers against decapentaplegic homolog 9

1

8

High-throughput

0.508

High

738101

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

Small-scale

0.508

High

935329

H31
Histone H3.1

1

13

Small-scale

0.501

High

1307032

ANM1
Protein arginine N-methyltransferase 1

1

12

Small-scale

0.501

High

725710

ACTN2
Alpha-actinin-2

1

1

High-throughput

0.494

High

932425

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.494

High

962516

MYPC1
Myosin-binding protein C, slow-type

1

9

High-throughput

0.494

High

1138251

MYOM3
Myomesin-3

1

9

High-throughput

0.494

High

1264814

TITIN
Titin

1

11

High-throughput

0.494

High

537778

INSRR
Insulin receptor-related protein

1

7

High-throughput

0.489

High

1252818

ARRD2
Arrestin domain-containing protein 2

1

6

High-throughput

0.489

High

1305971

BARD1
BRCA1-associated RING domain protein 1

1

7

High-throughput

0.481

High

1354083

DNM3L
DNA

1

0

Small-scale

0.480

High

61769

BDP1
Transcription factor TFIIIB component B'' homolog

1

9

High-throughput

0.479

High

63150

CCD69
Coiled-coil domain-containing protein 69

1

1

High-throughput

0.479

High

163411

XPO1
Exportin-1

1

4

High-throughput

0.479

High

165879

KDM6B
Lysine-specific demethylase 6B

1

12

Small-scale

0.479

High

225431

MED14
Mediator of RNA polymerase II transcription subunit 14

1

11

Small-scale

0.479

High

229819

ZN292
Zinc finger protein 292

1

2

High-throughput

0.479

High

266068

PSIP1
PC4 and SFRS1-interacting protein

1

6

High-throughput

0.479

High

301161

KDM4B
Lysine-specific demethylase 4B

1

4

Small-scale

0.479

High

322032

ZMYM6
Zinc finger MYM-type protein 6

1

1

High-throughput

0.479

High

345564

FOS
Protein c-Fos

1

6

High-throughput

0.479

High

348134

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

377771

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

416721

S10A6
Protein S100-A6

1

4

High-throughput

0.479

High

446825

SNRPA
U1 small nuclear ribonucleoprotein A

1

8

Small-scale

0.479

High

455962

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.479

High

486840

MYB
Transcriptional activator Myb

1

5

Small-scale

0.479

High

546052

MYOD1
Myoblast determination protein 1

1

1

High-throughput

0.479

High

570142

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

620217

PAX7
Paired box protein Pax-7

1

5

Small-scale

0.479

High

632938

TYY1
Transcriptional repressor protein YY1

1

4

High-throughput

0.479

High

641587

PAX6
Paired box protein Pax-6

1

4

High-throughput

0.479

High

672910

CDC27
Cell division cycle protein 27 homolog

1

3

Small-scale

0.479

High

692196

ELF1
ETS-related transcription factor Elf-1

1

14

High-throughput

0.479

High

707777

H2B1B
Histone H2B type 1-B

1

10

High-throughput

0.479

High

739333

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.479

High

782681

HNF4A
Hepatocyte nuclear factor 4-alpha

1

18

High-throughput

0.479

High

808985

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

839837

LHX2
LIM/homeobox protein Lhx2

1

1

High-throughput

0.479

High

853743

IMA5
Importin subunit alpha-5

1

4

Small-scale

0.479

High

872313

RD23B
UV excision repair protein RAD23 homolog B

1

5

High-throughput

0.479

High

877930

FOXA1
Hepatocyte nuclear factor 3-alpha

1

13

High-throughput

0.479

High

882999

RBM11
Splicing regulator RBM11

1

15

High-throughput

0.479

High

918749

H2B1C
Histone H2B type 1-C/E/F/G/I

1

10

High-throughput

0.479

High

934534

CSK21
Casein kinase II subunit alpha

1

6

High-throughput

0.479

High

952889

FOXK1
Forkhead box protein K1

1

11

High-throughput

0.479

High

963695

E2F1
Transcription factor E2F1

1

3

Small-scale

0.479

High

964276

FOXK2
Forkhead box protein K2

1

11

High-throughput

0.479

High

964453

RUNX1
Runt-related transcription factor 1

1

3

High-throughput

0.479

High

1019155

TP53B
TP53-binding protein 1

1

9

High-throughput

0.479

High

1023355

TRI32
E3 ubiquitin-protein ligase TRIM32

1

4

Small-scale

0.479

High

1034639

GOGA4
Golgin subfamily A member 4

1

10

Small-scale

0.479

High

1040847

PWP1
Periodic tryptophan protein 1 homolog

1

16

High-throughput

0.479

High

1042737

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1057010

MDC1
Mediator of DNA damage checkpoint protein 1

1

13

High-throughput

0.479

High

1060382

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

1063662

SUZ12
Polycomb protein SUZ12

1

6

High-throughput

0.479

High

1078689

SMAD2
Mothers against decapentaplegic homolog 2

1

8

Small-scale

0.479

High

1078768

SMAD1
Mothers against decapentaplegic homolog 1

1

8

Small-scale

0.479

High

1081429

E2F4
Transcription factor E2F4

1

3

Small-scale

0.479

High

1157913

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

1

High-throughput

0.479

High

1188204

KANL1
KAT8 regulatory NSL complex subunit 1

1

1

High-throughput

0.479

High

1218729

MGAP
MAX gene-associated protein

1

2

High-throughput

0.479

High

1222862

SRRM1
Serine/arginine repetitive matrix protein 1

1

11

High-throughput

0.479

High

1223203

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

1236549

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1242582

RB15B
Putative RNA-binding protein 15B

1

3

Small-scale

0.479

High

1242676

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

9

Small-scale

0.479

High

1254948

SP7
Transcription factor Sp7

1

9

High-throughput

0.479

High

1256453

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1267214

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1268054

JADE3
Protein Jade-3

1

16

High-throughput

0.479

High

1269829

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1270719

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1273089

FUBP2
Far upstream element-binding protein 2

1

19

High-throughput

0.479

High

1290772

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

1304904

ELF4
ETS-related transcription factor Elf-4

1

13

High-throughput

0.479

High

1326766

WWTR1
WW domain-containing transcription regulator protein 1

1

16

High-throughput

0.479

High

1332327

SOX17
Transcription factor SOX-17

1

15

High-throughput

0.479

High

1333498

CSR2B
Cysteine-rich protein 2-binding protein

1

10

High-throughput

0.479

High

1334368

KANL2
KAT8 regulatory NSL complex subunit 2

1

1

High-throughput

0.479

High

1343285

JADE2
E3 ubiquitin-protein ligase Jade-2

1

10

High-throughput

0.479

High

1348878

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1350470

KANL3
KAT8 regulatory NSL complex subunit 3

1

2

High-throughput

0.479

High

1350532

RERE
Arginine-glutamic acid dipeptide repeats protein

1

16

High-throughput

0.479

High

1354081

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1354084

YETS2
YEATS domain-containing protein 2

1

8

High-throughput

0.479

High

1354086

PHF8
Histone lysine demethylase PHF8

1

11

Small-scale

0.479

High

1354088

ICE1
Little elongation complex subunit 1

1

1

High-throughput

0.479

High

1354093

LOXL2
Lysyl oxidase homolog 2

1

4

Small-scale

0.479

High

265563

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

5

High-throughput

0.470

High

243653

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.458

High

344808

TIMP1
Metalloproteinase inhibitor 1

1

0

Small-scale

0.458

High

798773

PRS6B
26S proteasome regulatory subunit 6B

1

0

Small-scale

0.458

High

847918

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.458

High

1036497

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

Small-scale

0.458

High

1048014

COX17
Cytochrome c oxidase copper chaperone

1

0

Small-scale

0.458

High

1059599

MEF2D
Myocyte-specific enhancer factor 2D

1

0

Small-scale

0.458

High

1072324

ELOC
Elongin-C

1

0

Small-scale

0.458

High

1253127

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

High-throughput

0.458

High

1260940

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1296592

CAZA3
F-actin-capping protein subunit alpha-3

1

0

High-throughput

0.458

High

1349199

SACS
Sacsin

1

0

Small-scale

0.458

High

1354090

PDIP2
Polymerase delta-interacting protein 2

1

0

Small-scale

0.458

High

1354095

SETBP
SET-binding protein

1

0

Small-scale

0.458

High

321232

PTBP3
Polypyrimidine tract-binding protein 3

1

5

High-throughput

0.445

High

1044229

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.445

High

1153425

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1202784

WDR5B
WD repeat-containing protein 5B

1

14

Small-scale

0.445

High

1302462

SIN3A
Paired amphipathic helix protein Sin3a

1

2

Small-scale

0.445

High

1349126

GRHL1
Grainyhead-like protein 1 homolog

1

3

High-throughput

0.445

High

603255

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

Small-scale

0.437

High

1072667

RHEB
GTP-binding protein Rheb

1

2

Small-scale

0.437

High

1221042

MSRB3
Methionine-R-sulfoxide reductase B3

1

1

Small-scale

0.437

High

1346364

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

1

1

High-throughput

0.437

High

1350060

RCC2
Protein RCC2

1

2

High-throughput

0.437

High

1354092

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

1

Small-scale

0.437

High

1058410

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

1034208

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.282

High

885755

CU058
Uncharacterized protein C21orf58

1

0

High-throughput

0.279

Low

1229918

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

1285634

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.279

Low

1297598

KAD7
Adenylate kinase 7

1

0

High-throughput

0.279

Low

1354091

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.279

Low

314898

FMNL1
Formin-like protein 1

1

0

Small-scale

0.249

Low

847387

SSRD
Translocon-associated protein subunit delta

1

0

Small-scale

0.249

Low

1065450

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

Small-scale

0.249

Low

1329588

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

Small-scale

0.249

Low

1333487

Q9H8E5
cDNA FLJ13705 fis, clone PLACE2000302

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024