Protein: MK13
Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)

Gene: MK13, MAPK13
Organism: Homo sapiens
Interactions: 121
UniProt ID: O15264

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

184610

MK12
Mitogen-activated protein kinase 12

4

19

High-throughput

0.903

High

62858

POTEF
POTE ankyrin domain family member F

3

7

High-throughput

0.848

High

184636

KPCD1
Serine/threonine-protein kinase D1

1

20

Small-scale

0.710

High

184558

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

184559

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

184578

FPR1
fMet-Leu-Phe receptor

1

5

Small-scale

0.691

High

184631

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

9

High-throughput

0.691

High

184639

KS6A2
Ribosomal protein S6 kinase alpha-2

1

20

High-throughput

0.691

High

184640

KS6A1
Ribosomal protein S6 kinase alpha-1

1

20

High-throughput

0.691

High

184641

CDC37
Hsp90 co-chaperone Cdc37

1

9

High-throughput

0.691

High

184592

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

High-throughput

0.680

High

184633

SQSTM
Sequestosome-1

1

9

Small-scale

0.647

High

184572

ATF2
Cyclic AMP-dependent transcription factor ATF-2

3

20

Small-scale

0.633

High

184563

TAU
Microtubule-associated protein tau

2

19

Small-scale

0.629

High

184548

RASK
GTPase KRas

1

8

High-throughput

0.618

High

184606

TCPG
T-complex protein 1 subunit gamma

2

17

Small-scale

0.601

High

184609

TCPD
T-complex protein 1 subunit delta

2

15

Small-scale

0.601

High

184630

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

12

Small-scale

0.584

High

184560

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

11

Small-scale

0.575

High

184565

PABP1
Polyadenylate-binding protein 1

1

7

Small-scale

0.575

High

184569

PLST
Plastin-3

1

13

Small-scale

0.575

High

184571

ENPL
Endoplasmin

1

20

Small-scale

0.575

High

184577

NUCL
Nucleolin

1

6

Small-scale

0.575

High

184581

SFPQ
Splicing factor, proline- and glutamine-rich

1

12

Small-scale

0.575

High

184595

FUS
RNA-binding protein FUS

1

7

Small-scale

0.575

High

184620

RAN
GTP-binding nuclear protein Ran

1

2

Small-scale

0.575

High

184629

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

Small-scale

0.575

High

184638

NONO
Non-POU domain-containing octamer-binding protein

1

13

Small-scale

0.575

High

184643

MAPK5
MAP kinase-activated protein kinase 5

1

20

Small-scale

0.575

High

184646

TFG
Protein TFG

1

5

Small-scale

0.575

High

184647

RBP56
TATA-binding protein-associated factor 2N

1

4

Small-scale

0.575

High

184659

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

13

Small-scale

0.575

High

184657

FBW1A
F-box/WD repeat-containing protein 1A

1

14

Small-scale

0.552

High

184642

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.549

High

184611

DRG2
Developmentally-regulated GTP-binding protein 2

1

1

High-throughput

0.536

High

184596

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

0

High-throughput

0.518

High

184614

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

184632

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.508

High

184543

HTRA2
Serine protease HTRA2, mitochondrial

1

5

Small-scale

0.501

High

184549

MBP
Myelin basic protein

1

10

Small-scale

0.501

High

184552

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

184617

FGF12
Fibroblast growth factor 12

1

1

Small-scale

0.501

High

184655

COHA1
Collagen alpha-1(XVII) chain

1

1

High-throughput

0.489

High

184573

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

184586

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

184599

STAT3
Signal transducer and activator of transcription 3

1

8

Small-scale

0.479

High

184612

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

184627

EP300
Histone acetyltransferase p300

1

15

Small-scale

0.479

High

144341

PDXK
Pyridoxal kinase

1

0

High-throughput

0.458

High

141208

DDX3X
ATP-dependent RNA helicase DDX3X

1

7

Small-scale

0.445

High

184542

SERA
D-3-phosphoglycerate dehydrogenase

1

4

Small-scale

0.445

High

184544

IF2P
Eukaryotic translation initiation factor 5B

1

10

Small-scale

0.445

High

184546

LDHA
L-lactate dehydrogenase A chain

1

9

Small-scale

0.445

High

184547

PGK1
Phosphoglycerate kinase 1

1

2

Small-scale

0.445

High

184550

ALDOA
Fructose-bisphosphate aldolase A

1

2

Small-scale

0.445

High

184551

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

5

Small-scale

0.445

High

184553

RLA2
Large ribosomal subunit protein P2

1

3

Small-scale

0.445

High

184554

ENOA
Alpha-enolase

1

3

Small-scale

0.445

High

184555

LDHB
L-lactate dehydrogenase B chain

1

9

Small-scale

0.445

High

184556

PROF1
Profilin-1

1

3

Small-scale

0.445

High

184557

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

6

Small-scale

0.445

High

184561

PARP1
Poly [ADP-ribose] polymerase 1

1

10

Small-scale

0.445

High

184562

H14
Histone H1.4

1

10

Small-scale

0.445

High

184564

BIP
Endoplasmic reticulum chaperone BiP

1

14

Small-scale

0.445

High

184566

KCRB
Creatine kinase B-type

1

1

Small-scale

0.445

High

184567

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.445

High

184568

EF2
Elongation factor 2

1

8

Small-scale

0.445

High

184570

KPYM
Pyruvate kinase PKM

1

6

Small-scale

0.445

High

184574

CBR1
Carbonyl reductase [NADPH] 1

1

4

Small-scale

0.445

High

184575

H12
Histone H1.2

1

10

Small-scale

0.445

High

184576

PGAM1
Phosphoglycerate mutase 1

1

2

Small-scale

0.445

High

184579

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

Small-scale

0.445

High

184580

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.445

High

184582

RS3
Small ribosomal subunit protein uS3

1

2

Small-scale

0.445

High

184583

SAHH
Adenosylhomocysteinase

1

1

Small-scale

0.445

High

184584

EF1B
Elongation factor 1-beta

1

4

Small-scale

0.445

High

184585

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

7

Small-scale

0.445

High

184588

EF1D
Elongation factor 1-delta

1

4

Small-scale

0.445

High

184589

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

Small-scale

0.445

High

184590

PRDX6
Peroxiredoxin-6

1

10

Small-scale

0.445

High

184591

PDIA3
Protein disulfide-isomerase A3

1

5

Small-scale

0.445

High

184593

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.445

High

184594

STIP1
Stress-induced-phosphoprotein 1

1

5

Small-scale

0.445

High

184597

TAGL2
Transgelin-2

1

13

Small-scale

0.445

High

184598

TCPZ
T-complex protein 1 subunit zeta

1

16

Small-scale

0.445

High

184600

MDHM
Malate dehydrogenase, mitochondrial

1

9

Small-scale

0.445

High

184602

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

9

Small-scale

0.445

High

184603

TCPE
T-complex protein 1 subunit epsilon

1

18

Small-scale

0.445

High

184604

NASP
Nuclear autoantigenic sperm protein

1

3

Small-scale

0.445

High

184605

FAS
Fatty acid synthase

1

4

Small-scale

0.445

High

184607

GDIB
Rab GDP dissociation inhibitor beta

1

1

Small-scale

0.445

High

184608

TCPQ
T-complex protein 1 subunit theta

1

20

Small-scale

0.445

High

184615

IF4A1
Eukaryotic initiation factor 4A-I

1

11

Small-scale

0.445

High

184616

ARF3
ADP-ribosylation factor 3

1

3

Small-scale

0.445

High

184618

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

11

Small-scale

0.445

High

184619

RS14
Small ribosomal subunit protein uS11

1

3

Small-scale

0.445

High

184621

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.445

High

184622

YBOX1
Y-box-binding protein 1

1

4

Small-scale

0.445

High

184623

EF1A1
Elongation factor 1-alpha 1

1

6

Small-scale

0.445

High

184624

TCPB
T-complex protein 1 subunit beta

1

18

Small-scale

0.445

High

184625

CLH1
Clathrin heavy chain 1

1

3

Small-scale

0.445

High

184626

DHX9
ATP-dependent RNA helicase A

1

2

Small-scale

0.445

High

184628

ILF3
Interleukin enhancer-binding factor 3

1

5

Small-scale

0.445

High

184644

SERB1
SERPINE1 mRNA-binding protein 1

1

4

Small-scale

0.445

High

184645

DDX1
ATP-dependent RNA helicase DDX1

1

12

Small-scale

0.445

High

184650

NP1L4
Nucleosome assembly protein 1-like 4

1

3

Small-scale

0.445

High

184652

CYBP
Calcyclin-binding protein

1

1

Small-scale

0.445

High

184545

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

184601

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

0

Small-scale

0.426

High

184637

IPYR
Inorganic pyrophosphatase

1

0

Small-scale

0.426

High

184651

HAUS4
HAUS augmin-like complex subunit 4

1

0

High-throughput

0.426

High

184654

ARMX3
Armadillo repeat-containing X-linked protein 3

1

0

High-throughput

0.426

High

184656

NUDC
Nuclear migration protein nudC

1

0

Small-scale

0.426

High

184587

CALX
Calnexin

1

2

Small-scale

0.407

High

184634

GANAB
Neutral alpha-glucosidase AB

1

5

Small-scale

0.407

High

184635

PDIA6
Protein disulfide-isomerase A6

1

5

Small-scale

0.407

High

184648

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

1

High-throughput

0.407

High

184649

EFGM
Elongation factor G, mitochondrial

1

8

Small-scale

0.407

High

184658

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.407

High

184653

AKIP1
A-kinase-interacting protein 1

1

0

High-throughput

0.265

Low

184613

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025