HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 545 Hs			1 636
+	Mm
		711009 AIRE_MOUSE (16-544): 2.94e-123: 374: 71.72		PABP1_MOUSE (1-636): 0: 570: 99.69
+	Hs
		550289 CHD4_HUMAN (74-489): 2.07e-30: 128: 13.43		PABP1_HUMAN (1-636): 0: 571: 100.00
+	Hs
		550249 CHD3_HUMAN (74-503): 9.27e-27: 117: 14.16		PABP1_HUMAN (1-636): 0: 571: 100.00
+	Hs
		550523 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		PABP1_HUMAN (1-636): 0: 571: 100.00
+	Hs
		1101959 CHD4_HUMAN (74-489): 2.07e-30: 128: 13.43		PABP4_HUMAN (1-635): 4.43e-180: 527: 72.87
+	Hs
		1088320 CHD3_HUMAN (74-503): 9.27e-27: 117: 14.16		PABP4_HUMAN (1-635): 4.43e-180: 527: 72.87
+	Hs
		550417 NSD1_HUMAN (285-383): 1.69e-11: 69.4: 30.69		PABP1_HUMAN (1-636): 0: 571: 100.00
+	Sc
		403565 JHD2_YEAST (287-341): 3.22e-10: 64.7: 43.10		PABP_YEAST (2-289): 9.7e-65: 225: 30.82
+	Hs
		620371 CHD4_HUMAN (74-489): 2.07e-30: 128: 13.43		NUCL_HUMAN (3-89): 4.28e-20: 96.8: 33.33
+	Hs
		620536 UHRF1_HUMAN (268-410): 2.96e-28: 121: 23.87		NUCL_HUMAN (3-89): 4.28e-20: 96.8: 33.33
+	Hs
		620329 CHD3_HUMAN (74-503): 9.27e-27: 117: 14.16		NUCL_HUMAN (3-89): 4.28e-20: 96.8: 33.33
+	Hs
		355428 NSD2_HUMAN (30-345): 3.1e-17: 87.5: 14.80		NUCL_HUMAN (3-89): 4.28e-20: 96.8: 33.33