Protein: JHD2
Histone demethylase JHD2 (EC 1.14.11.67) (Jumonji/ARID domain-containing protein 2) ([histone H3]-trimethyl-L-lysine(4) demethylase JHD2)

Gene: JHD2
Organism: Saccharomyces cerevisiae S288C
Interactions: 47
UniProt ID: P47156

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000278 - mitotic cell cycle
GO:0000785 - chromatin
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

866138

H3
Histone H3

5

20

Small-scale

0.917

High

866134

JHD2
Histone demethylase JHD2

2

13

Small-scale

0.768

High

419457

H2A1
Histone H2A.1

1

1

Small-scale

0.647

High

740983

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

2

Small-scale

0.618

High

866145

YRA1
RNA annealing protein YRA1

1

2

Small-scale

0.618

High

866146

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

2

Small-scale

0.618

High

403565

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.586

High

441382

KAPB
cAMP-dependent protein kinase type 2

1

3

Small-scale

0.561

High

671450

RNA15
mRNA 3'-end-processing protein RNA15

1

1

Small-scale

0.553

High

819175

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.552

High

726048

FUN30
ATP-dependent helicase FUN30

1

11

High-throughput

0.515

High

761125

NOT4
General negative regulator of transcription subunit 4

1

2

Small-scale

0.501

High

800725

RCK1
Serine/threonine-protein kinase RCK1

1

2

High-throughput

0.501

High

866139

SKY1
Serine/threonine-protein kinase SKY1

1

3

High-throughput

0.501

High

825535

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.493

High

866144

SAS10
Something about silencing protein 10

1

0

High-throughput

0.493

High

557744

SRS2
ATP-dependent DNA helicase SRS2

1

1

Small-scale

0.481

High

394697

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.479

High

437937

KAPC
cAMP-dependent protein kinase type 3

1

4

Small-scale

0.479

High

441184

KAPA
cAMP-dependent protein kinase type 1

1

4

Small-scale

0.479

High

776482

MPE1
Protein MPE1

1

1

Small-scale

0.479

High

843171

PFS2
Polyadenylation factor subunit 2

1

10

Small-scale

0.479

High

866135

SAP4
SIT4-associating protein SAP4

1

1

High-throughput

0.479

High

866137

PBP1
PAB1-binding protein 1

1

1

Small-scale

0.479

High

866141

PBP4
Protein PBP4

1

1

Small-scale

0.479

High

454747

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

671422

RNA14
mRNA 3'-end-processing protein RNA14

1

0

Small-scale

0.458

High

694588

SPT5
Transcription elongation factor SPT5

1

0

Small-scale

0.458

High

712930

PAP
Poly(A) polymerase

1

0

Small-scale

0.458

High

805606

LSM12
Protein LSM12

1

0

Small-scale

0.458

High

811217

PCF11
Protein PCF11

1

0

Small-scale

0.458

High

814983

PTI1
Protein PTI1

1

0

Small-scale

0.458

High

837278

REF2
RNA end formation protein 2

1

0

Small-scale

0.458

High

853578

FIP1
Pre-mRNA polyadenylation factor FIP1

1

0

Small-scale

0.458

High

866142

SUB2
ATP-dependent RNA helicase SUB2

1

0

Small-scale

0.458

High

866143

CFT2
Cleavage factor two protein 2

1

0

Small-scale

0.458

High

524448

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

527081

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

545443

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

579689

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.445

High

670890

SIS1
Protein SIS1

1

2

High-throughput

0.445

High

741908

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

816285

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.445

High

866140

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.407

High

784388

RM36
Large ribosomal subunit protein bL31m

1

0

High-throughput

0.249

Low

866136

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025