Protein: AIRE
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog)

Gene: AIRE
Organism: Mus musculus
Interactions: 50
UniProt ID: Q9Z0E3

Gene Ontology (top 5):
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001673 - male germ cell nucleus
GO:0001674 - female germ cell nucleus
GO:0002458 - peripheral T cell tolerance induction
GO:0002509 - central tolerance induction to self antigen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491891

AIRE
Autoimmune regulator

1

19

Small-scale

0.665

High

61331

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

17

Small-scale

0.575

High

87174

H2A1B
Histone H2A type 1-B

1

20

Small-scale

0.575

High

711009

PABP1
Polyadenylate-binding protein 1

1

12

Small-scale

0.575

High

999040

H31
Histone H3.1

1

20

Small-scale

0.575

High

1016706

SRSF3
Serine/arginine-rich splicing factor 3

1

20

Small-scale

0.575

High

1223534

SRSF2
Serine/arginine-rich splicing factor 2

1

14

Small-scale

0.575

High

1224082

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.575

High

1243948

SRSF1
Serine/arginine-rich splicing factor 1

1

20

Small-scale

0.575

High

1225801

H2B2B
Histone H2B type 2-B

1

20

Small-scale

0.514

High

1408870

TLR3
Toll-like receptor 3

1

8

Small-scale

0.479

High

148373

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

Small-scale

0.445

High

205344

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.445

High

476250

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.445

High

536227

PARP1
Poly [ADP-ribose] polymerase 1

1

20

Small-scale

0.445

High

575084

LMNB1
Lamin-B1

1

20

Small-scale

0.445

High

609556

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.445

High

690162

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

3

Small-scale

0.445

High

846717

MSH2
DNA mismatch repair protein Msh2

1

7

Small-scale

0.445

High

887493

MCM5
DNA replication licensing factor MCM5

1

20

Small-scale

0.445

High

928610

MSH6
DNA mismatch repair protein Msh6

1

10

Small-scale

0.445

High

974892

SMD3
Small nuclear ribonucleoprotein Sm D3

1

5

Small-scale

0.445

High

999474

RANB9
Ran-binding protein 9

1

20

Small-scale

0.445

High

1021123

MCM2
DNA replication licensing factor MCM2

1

20

Small-scale

0.445

High

1021136

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.445

High

1021142

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

Small-scale

0.445

High

1030132

TOP2A
DNA topoisomerase 2-alpha

1

9

Small-scale

0.445

High

1223007

RAD21
Double-strand-break repair protein rad21 homolog

1

3

Small-scale

0.445

High

1223194

DDX5
Probable ATP-dependent RNA helicase DDX5

1

18

Small-scale

0.445

High

1242745

XPO1
Exportin-1

1

13

Small-scale

0.445

High

1253433

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

11

Small-scale

0.445

High

1274509

MBB1A
Myb-binding protein 1A

1

5

Small-scale

0.445

High

1298433

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

Small-scale

0.445

High

1362483

SP16H
FACT complex subunit SPT16

1

5

Small-scale

0.445

High

1408871

NASP
Nuclear autoantigenic sperm protein

1

4

Small-scale

0.445

High

1423810

SMC1A
Structural maintenance of chromosomes protein 1A

1

20

Small-scale

0.445

High

1423825

SMC3
Structural maintenance of chromosomes protein 3

1

13

Small-scale

0.445

High

1424116

NOP56
Nucleolar protein 56

1

9

Small-scale

0.445

High

1424357

IPO7
Importin-7

1

7

Small-scale

0.445

High

1424420

RBP2
E3 SUMO-protein ligase RanBP2

1

9

Small-scale

0.445

High

1490126

RUVB2
RuvB-like 2

1

5

Small-scale

0.445

High

946625

TLR8
Toll-like receptor 8

1

8

Small-scale

0.437

High

1424359

TLR1
Toll-like receptor 1

1

2

Small-scale

0.437

High

999778

IMB1
Importin subunit beta-1

1

12

Small-scale

0.407

High

1190272

Q3UHQ5
Stalled ribosome sensor GCN1

1

7

Small-scale

0.407

High

1197472

DDX17
Probable ATP-dependent RNA helicase DDX17

1

18

Small-scale

0.407

High

1296796

NUP93
Nuclear pore complex protein Nup93

1

1

Small-scale

0.407

High

1297526

GEMI5
Gem-associated protein 5

1

16

Small-scale

0.407

High

1423789

XPOT
Exportin-T

1

9

Small-scale

0.407

High


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Last updated: 11Aug2025