HitPredict

Interactor 1: PCNA (P15873)
Proliferating cell nuclear antigen (PCNA)
Gene: POL30

Interactor 2: FEN1 (P26793)
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1) (RAD2 homolog nuclease 1) (RTH1 nuclease) (Structure-specific endonuclease RAD27)
Gene: RAD27

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.951

Property	Details
Experiments	20967232, 11805837, 15965249, 16554755, 22308326, 7673186
Identification Methods	two hybrid, solid phase assay, anti tag coimmunoprecipitation, affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PCNA_C~XPG_I, PCNA_C~XPG_N, PCNA_N~XPG_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0035753 - maintenance of DNA trinucleotide repeats
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 258 Sc			1 382
+	Hs
		517111 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		FEN1_HUMAN (1-382): 7.91e-143: 412: 56.88
+	Dm
		572183 PCNA_DROME (1-258): 7.5e-110: 318: 35.91		FEN1_DROME (1-381): 8.58e-139: 402: 53.91
+	Hs
		238257 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		FEN1_HUMAN (1-382): 7.91e-143: 412: 56.88
+	Hs
		517542 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		EXO1_HUMAN (1-379): 6.8e-93: 298: 23.51
+	Hs
		517072 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		ERCC5_HUMAN (1-130): 5.27e-31: 126: 29.23
+	Sc
		550549 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		YEN1_YEAST (1-249): 1.59e-40: 154: 18.18
+	Sc
		425538 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		RAD2_YEAST (1-130): 7.03e-30: 123: 29.23