HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 2799
+	Hs
		304318 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		304418 MYH4_HUMAN (1242-1756): 4.37e-20: 100: 12.93		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		304161 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		304018 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		304122 SPTB2_HUMAN (559-1683): 4.02e-10: 67.6: 11.36		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		724841 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33
+	Hs
		1336100 DAPLE_HUMAN (904-1656): 9.25e-20: 99.3: 15.56		SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18
+	Hs
		1045530 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18
+	Hs
		1350503 MACF1_HUMAN (498-1680): 1.71e-12: 75.4: 12.90		HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72
+	Hs
		1061257 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18
+	Hs
		551845 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18
+	Hs
		1192196 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27
+	Hs
		1113852 GRDN_HUMAN (1065-1598): 6.32e-11: 70.1: 23.13		SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18
+	Hs
		963426 SPTB2_HUMAN (559-1683): 4.02e-10: 67.6: 11.36		SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18
+	Hs
		125464 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94
+	Hs
		724896 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27
+	Hs
		1113845 GRDN_HUMAN (1065-1598): 6.32e-11: 70.1: 23.13		WWP1_HUMAN (2180-2797): 2.84e-126: 425: 18.43
+	Hs
		506823 SPTB1_HUMAN (189-1505): 5e-14: 80.3: 10.93		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27
+	Mm
		1143711 SPTB2_MOUSE (506-1755): 2.99e-10: 67.9: 9.67		HUWE1_MOUSE (2499-2798): 9.29e-101: 367: 27.27
+	Hs
		724789 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93