HitPredict

Interactor 1: ACSL4 (O60488)
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)
Gene: ACSL4

Interactor 2: ACSL3 (O95573)
Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)
Gene: ACSL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

The method score is based on:

Property	Details
Experiments	26496610, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	AMP-binding~AMP-binding
Common GO terms	GO:0001676 - long-chain fatty acid metabolic process GO:0004467 - long-chain fatty acid-CoA ligase activity GO:0005524 - ATP binding GO:0005741 - mitochondrial outer membrane GO:0005778 - peroxisomal membrane and 11 others more... GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005811 - lipid droplet GO:0005886 - plasma membrane GO:0006631 - fatty acid metabolic process GO:0016020 - membrane GO:0030182 - neuron differentiation GO:0035336 - long-chain fatty-acyl-CoA metabolic process GO:0035338 - long-chain fatty-acyl-CoA biosynthetic process GO:0047676 - arachidonate-CoA ligase activity GO:0090433 - palmitoyl-CoA ligase activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	711
Hs

1	720

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024