Protein: ACLY
ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)

Gene: ACLY
Organism: Homo sapiens
Interactions: 233
UniProt ID: P53396

Gene Ontology (top 5):
GO:0003878 - ATP citrate synthase activity
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

920768

ACLY
ATP-citrate synthase

5

12

Small-scale

0.903

High

920798

CUL3
Cullin-3

4

5

Small-scale

0.698

High

507713

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

5

Small-scale

0.646

High

241174

PRKN
E3 ubiquitin-protein ligase parkin

3

5

High-throughput

0.640

High

371544

MYC
Myc proto-oncogene protein

3

4

High-throughput

0.640

High

711284

SHC1
SHC-transforming protein 1

3

2

High-throughput

0.633

High

920888

KLH25
Kelch-like protein 25

2

0

Small-scale

0.607

High

425395

ISG15
Ubiquitin-like protein ISG15

2

6

High-throughput

0.601

High

563464

CFTR
Cystic fibrosis transmembrane conductance regulator

2

4

High-throughput

0.601

High

648115

NDKB
Nucleoside diphosphate kinase B

2

1

Small-scale

0.601

High

891392

GSK3B
Glycogen synthase kinase-3 beta

2

1

High-throughput

0.601

High

400525

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

5

High-throughput

0.584

High

830399

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

920792

EP300
Histone acetyltransferase p300

2

1

High-throughput

0.584

High

920866

FBXW7
F-box/WD repeat-containing protein 7

2

3

Small-scale

0.584

High

920771

TERA
Transitional endoplasmic reticulum ATPase

2

3

High-throughput

0.571

High

920810

KPCD1
Serine/threonine-protein kinase D1

2

2

High-throughput

0.571

High

920818

PKHG6
Pleckstrin homology domain-containing family G member 6

2

3

High-throughput

0.571

High

345557

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

920769

ATX3
Ataxin-3

2

0

Small-scale

0.559

High

920824

UBR4
E3 ubiquitin-protein ligase UBR4

2

0

Small-scale

0.559

High

920882

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

717733

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.554

High

920780

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.554

High

920784

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.554

High

920826

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

3

High-throughput

0.554

High

920912

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

3

High-throughput

0.554

High

389176

FINC
Fibronectin

1

1

High-throughput

0.536

High

529400

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.536

High

843407

HD
Huntingtin

1

3

High-throughput

0.536

High

905528

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

920789

KPCZ
Protein kinase C zeta type

1

2

High-throughput

0.536

High

920797

CUL2
Cullin-2

1

5

High-throughput

0.536

High

920812

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

920816

AAK1
AP2-associated protein kinase 1

1

1

High-throughput

0.536

High

920841

PIM3
Serine/threonine-protein kinase pim-3

1

2

High-throughput

0.536

High

920842

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

High-throughput

0.536

High

920844

MYLK4
Myosin light chain kinase family member 4

1

3

High-throughput

0.536

High

920856

MK15
Mitogen-activated protein kinase 15

1

1

High-throughput

0.536

High

920857

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

920867

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

High-throughput

0.536

High

920881

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

920895

PAK6
Serine/threonine-protein kinase PAK 6

1

4

High-throughput

0.536

High

920909

PRP19
Pre-mRNA-processing factor 19

1

4

High-throughput

0.536

High

920918

TNPO3
Transportin-3

1

1

High-throughput

0.536

High

920919

SAR1B
Small COPII coat GTPase SAR1B

1

6

High-throughput

0.536

High

899792

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

842696

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

Small-scale

0.516

High

624230

TFE3
Transcription factor E3

1

3

High-throughput

0.515

High

863444

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.515

High

135555

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

187322

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

617284

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

0

High-throughput

0.513

High

919828

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

920773

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.513

High

920783

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

920835

HAKAI
E3 ubiquitin-protein ligase Hakai

1

0

Small-scale

0.513

High

920865

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

920800

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.493

High

920915

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.493

High

169483

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.480

High

421769

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

136857

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

2

High-throughput

0.479

High

213452

CTIF
CBP80/20-dependent translation initiation factor

1

1

Small-scale

0.479

High

227446

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

247270

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

5

High-throughput

0.479

High

920864

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

Small-scale

0.479

High

920868

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

920869

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

920870

OPTN
Optineurin

1

1

High-throughput

0.479

High

259671

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

272007

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.479

High

293412

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

294845

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

2

High-throughput

0.479

High

315321

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

336904

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

Small-scale

0.479

High

405934

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

411637

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

413462

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

420443

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.479

High

457327

TBB5
Tubulin beta chain

1

2

Small-scale

0.479

High

519870

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

536811

HSP7C
Heat shock cognate 71 kDa protein

1

4

Small-scale

0.479

High

573400

ENPL
Endoplasmin

1

3

High-throughput

0.479

High

588281

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

606484

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

683809

MOES
Moesin

1

2

High-throughput

0.479

High

695008

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

729197

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

Small-scale

0.479

High

731116

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

756136

MCM7
DNA replication licensing factor MCM7

1

3

Small-scale

0.479

High

764569

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

767772

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

791208

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

861939

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

878823

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

920770

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

920774

IF4A1
Eukaryotic initiation factor 4A-I

1

2

Small-scale

0.479

High

920776

MAX
Protein max

1

4

High-throughput

0.479

High

920777

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.479

High

920778

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

920779

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

920781

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.479

High

920788

ENL
Protein ENL

1

1

High-throughput

0.479

High

920793

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.479

High

920794

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

920795

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

920796

TBB3
Tubulin beta-3 chain

1

2

Small-scale

0.479

High

920802

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

2

Small-scale

0.479

High

920803

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

920808

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

920809

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

920811

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.479

High

920813

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

920819

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

920829

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

920832

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

3

High-throughput

0.479

High

920834

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

920838

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

920839

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

Small-scale

0.479

High

920843

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

920846

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

4

Small-scale

0.479

High

920851

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

Small-scale

0.479

High

920853

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

920859

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

920861

REQU
Zinc finger protein ubi-d4

1

2

High-throughput

0.479

High

920862

KAT2B
Histone acetyltransferase KAT2B

1

1

Small-scale

0.479

High

920863

TF3B
Transcription factor IIIB 90 kDa subunit

1

2

Small-scale

0.479

High

920873

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

920876

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

920877

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

920878

RIOK1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

920880

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

920885

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

920886

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

Small-scale

0.479

High

920889

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

Small-scale

0.479

High

920891

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.479

High

920893

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

920897

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

920898

HELLS
Lymphoid-specific helicase

1

3

Small-scale

0.479

High

920901

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

920905

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

920906

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

920908

ATD2B
ATPase family AAA domain-containing protein 2B

1

4

High-throughput

0.479

High

920910

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.479

High

920911

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

920916

TRAF6
TNF receptor-associated factor 6

1

2

Small-scale

0.479

High

920917

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

125344

LEG9
Galectin-9

1

0

High-throughput

0.458

High

174988

SC16A
Protein transport protein Sec16A

1

0

Small-scale

0.458

High

217993

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

247758

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

319557

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324666

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

349887

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

353138

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

399556

VTNC
Vitronectin

1

0

High-throughput

0.458

High

642743

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

658051

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

772116

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

798887

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

822548

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

898413

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

920775

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

920782

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

920785

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

920787

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

920801

TFDP2
Transcription factor Dp-2

1

0

High-throughput

0.458

High

920805

CUL7
Cullin-7

1

0

High-throughput

0.458

High

920806

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.458

High

920807

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

920815

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

920820

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

920825

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

920827

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

920830

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

920840

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

920845

DYH10
Dynein axonemal heavy chain 10

1

0

High-throughput

0.458

High

920847

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

920852

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

920855

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

920858

ASB15
Ankyrin repeat and SOCS box protein 15

1

0

High-throughput

0.458

High

920874

CIC
Protein capicua homolog

1

0

Small-scale

0.458

High

920879

DERL1
Derlin-1

1

0

Small-scale

0.458

High

920887

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

920890

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

920894

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

920896

ANLN
Anillin

1

0

High-throughput

0.458

High

920900

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

920902

PD1L1
Programmed cell death 1 ligand 1

1

0

Small-scale

0.458

High

920903

ATX10
Ataxin-10

1

0

High-throughput

0.458

High

920914

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

469418

ELNE
Neutrophil elastase

1

3

Small-scale

0.457

High

354610

PAK4
Serine/threonine-protein kinase PAK 4

1

4

High-throughput

0.445

High

429569

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

442905

PRGR
Progesterone receptor

1

2

Small-scale

0.445

High

920772

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

920823

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

920828

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.445

High

920860

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

105624

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

920790

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.437

High

920799

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.437

High

920814

CRY1
Cryptochrome-1

1

1

High-throughput

0.437

High

920817

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.437

High

920833

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

920836

KCTD9
BTB/POZ domain-containing protein KCTD9

1

3

High-throughput

0.437

High

920837

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

920849

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

920883

YTHD1
YTH domain-containing family protein 1

1

1

High-throughput

0.437

High

920892

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

920904

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

2

High-throughput

0.437

High

844245

MTHR
Methylenetetrahydrofolate reductase

1

0

Small-scale

0.426

High

920791

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.426

High

920850

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

920872

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

920875

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

920884

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

886669

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

920786

TAGL
Transgelin

1

1

High-throughput

0.407

High

920871

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

920848

DDIAS
DNA damage-induced apoptosis suppressor protein

1

0

Small-scale

0.251

Low

257397

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

276090

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

920821

DUS28
Dual specificity phosphatase 28

1

0

High-throughput

0.249

Low

920822

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

920831

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

920899

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

920907

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low

920913

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

920804

S29A2
Equilibrative nucleoside transporter 2

1

0

High-throughput

0.232

Low

920854

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025