HitPredict

Interactor 1: PIAS3 (O54714)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Interactor 2: SUMO1 (P63166)
Small ubiquitin-related modifier 1 (SUMO-1) (SMT3 homolog 3) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C)
Gene: SUMO1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	12387893
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0016607 - nuclear speck GO:0016925 - protein sumoylation GO:0098978 - glutamatergic synapse GO:0099523 - presynaptic cytosol and 1 others more... GO:0099524 - postsynaptic cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 628 Mm			1 101
+	Hs
		991472 PIAS3_HUMAN (1-628): 0: 706: 96.98		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	Hs
		964529 PIAS3_HUMAN (1-628): 0: 706: 96.98		SUMO2_HUMAN (1-97): 1.78e-38: 125: 45.36
+	Hs
		939243 PIAS3_HUMAN (1-628): 0: 706: 96.98		SUMO3_HUMAN (1-97): 1.66e-37: 123: 47.42
+	Hs
		297561 PIAS1_HUMAN (1-628): 0: 558: 56.54		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	Hs
		107789 PIAS1_HUMAN (1-628): 0: 558: 56.54		SUMO5_HUMAN (1-101): 4.54e-41: 132: 88.12
+	Hs
		297541 PIAS1_HUMAN (1-628): 0: 558: 56.54		SUMO2_HUMAN (1-97): 1.78e-38: 125: 45.36
+	Hs
		297530 PIAS1_HUMAN (1-628): 0: 558: 56.54		SUMO3_HUMAN (1-97): 1.66e-37: 123: 47.42
+	Hs
		297784 PIAS2_HUMAN (1-550): 0: 546: 56.70		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	Hs
		107790 PIAS2_HUMAN (1-550): 0: 546: 56.70		SUMO5_HUMAN (1-101): 4.54e-41: 132: 88.12
+	Hs
		297781 PIAS2_HUMAN (1-550): 0: 546: 56.70		SUMO2_HUMAN (1-97): 1.78e-38: 125: 45.36
+	Hs
		297778 PIAS2_HUMAN (1-550): 0: 546: 56.70		SUMO3_HUMAN (1-97): 1.66e-37: 123: 47.42
+	Rn
		1220400 PIAS2_RAT (1-540): 0: 530: 56.47		SUMO3_RAT (1-100): 1.51e-39: 128: 46.00
+	Hs
		991365 PIAS4_HUMAN (2-477): 2.7e-156: 460: 45.46		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	At
		1228125 SIZ1_ARATH (5-623): 6.74e-155: 469: 20.41		SUMO2_ARATH (6-99): 5.13e-38: 124: 45.75
+	At
		1228124 SIZ1_ARATH (5-623): 6.74e-155: 469: 20.41		SUMO3_ARATH (6-97): 1.88e-37: 123: 38.04
+	Rn
		81597 B5DFF9_RAT (2-477): 5.54e-153: 452: 45.11		SUMO1_RAT (1-101): 1.01e-41: 134: 100.00
+	At
		939035 SIZ1_ARATH (5-623): 6.74e-155: 469: 20.41		SUMO1_ARATH (9-95): 3.01e-35: 117: 47.13
+	Hs
		964366 PIAS4_HUMAN (2-477): 2.7e-156: 460: 45.46		SUMO2_HUMAN (1-97): 1.78e-38: 125: 45.36
+	Hs
		939211 PIAS4_HUMAN (2-477): 2.7e-156: 460: 45.46		SUMO3_HUMAN (1-97): 1.66e-37: 123: 47.42
+	Rn
		81598 B5DFF9_RAT (2-477): 5.54e-153: 452: 45.11		SUMO3_RAT (1-100): 1.51e-39: 128: 46.00