HitPredict

Interactor 1: B5DFF9 (B5DFF9)
E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma)
Gene: Pias4

Interactor 2: SUMO3 (Q5XIF4)
Small ubiquitin-related modifier 3 (SUMO-3)
Gene: SUMO3

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22082260
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0016604 - nuclear body GO:0016925 - protein sumoylation GO:0019789 - SUMO transferase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 507 Rn			1 110
+	Rn
		81597 B5DFF9_RAT (1-507): 0: 593: 100.00		SUMO1_RAT (1-95): 2.49e-39: 128: 47.00
+	Hs
		939211 PIAS4_HUMAN (1-507): 0: 576: 87.18		SUMO3_HUMAN (1-92): 1.41e-43: 139: 100.00
+	Hs
		964366 PIAS4_HUMAN (1-507): 0: 576: 87.18		SUMO2_HUMAN (1-92): 4.86e-42: 135: 96.77
+	Hs
		991365 PIAS4_HUMAN (1-507): 0: 576: 87.18		SUMO1_HUMAN (1-95): 2.49e-39: 128: 47.00
+	Rn
		1220400 PIAS2_RAT (3-503): 4.45e-161: 470: 44.99		SUMO3_RAT (1-110): 3.3e-56: 171: 100.00
+	Hs
		939243 PIAS3_HUMAN (3-506): 3.1e-166: 485: 46.04		SUMO3_HUMAN (1-92): 1.41e-43: 139: 100.00
+	Hs
		964529 PIAS3_HUMAN (3-506): 3.1e-166: 485: 46.04		SUMO2_HUMAN (1-92): 4.86e-42: 135: 96.77
+	Hs
		297530 PIAS1_HUMAN (3-505): 5.86e-164: 480: 44.34		SUMO3_HUMAN (1-92): 1.41e-43: 139: 100.00
+	Hs
		297541 PIAS1_HUMAN (3-505): 5.86e-164: 480: 44.34		SUMO2_HUMAN (1-92): 4.86e-42: 135: 96.77
+	Hs
		991472 PIAS3_HUMAN (3-506): 3.1e-166: 485: 46.04		SUMO1_HUMAN (1-95): 2.49e-39: 128: 47.00
+	Mm
		236336 PIAS3_MOUSE (3-506): 5.44e-164: 480: 45.84		SUMO1_MOUSE (1-95): 2.49e-39: 128: 47.00
+	Hs
		297561 PIAS1_HUMAN (3-505): 5.86e-164: 480: 44.34		SUMO1_HUMAN (1-95): 2.49e-39: 128: 47.00
+	Hs
		297778 PIAS2_HUMAN (3-503): 4.22e-159: 467: 45.37		SUMO3_HUMAN (1-92): 1.41e-43: 139: 100.00
+	Hs
		107789 PIAS1_HUMAN (3-505): 5.86e-164: 480: 44.34		SUMO5_HUMAN (1-95): 4.12e-38: 125: 45.00
+	Hs
		297781 PIAS2_HUMAN (3-503): 4.22e-159: 467: 45.37		SUMO2_HUMAN (1-92): 4.86e-42: 135: 96.77
+	Hs
		297784 PIAS2_HUMAN (3-503): 4.22e-159: 467: 45.37		SUMO1_HUMAN (1-95): 2.49e-39: 128: 47.00
+	Hs
		107790 PIAS2_HUMAN (3-503): 4.22e-159: 467: 45.37		SUMO5_HUMAN (1-95): 4.12e-38: 125: 45.00
+	At
		1228125 SIZ1_ARATH (3-483): 5.56e-127: 393: 20.29		SUMO2_ARATH (1-97): 4.86e-42: 135: 48.45
+	At
		939035 SIZ1_ARATH (3-483): 5.56e-127: 393: 20.29		SUMO1_ARATH (2-98): 1.08e-37: 124: 46.39
+	At
		1228124 SIZ1_ARATH (3-483): 5.56e-127: 393: 20.29		SUMO3_ARATH (1-92): 4.3e-37: 123: 41.94