HitPredict

Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21827211
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0032570 - response to progesterone
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 784 Hs			1 646
+	Hs
		120127 TLR4_HUMAN (11-782): 2.16e-83: 285: 22.77		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Mm
		926167 TLR4_MOUSE (1-782): 1.72e-81: 279: 21.33		HSP7C_MOUSE (1-646): 0: 967: 99.85
+	Mm
		926164 TLR9_MOUSE (6-533): 5.1e-33: 139: 15.95		HSP7C_MOUSE (1-646): 0: 967: 99.85
+	Hs
		504817 TLR9_HUMAN (3-269): 2.05e-24: 111: 14.18		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Hs
		564194 TLR9_HUMAN (3-269): 2.05e-24: 111: 14.18		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		871764 LGR4_HUMAN (44-189): 3.04e-16: 85.2: 25.75		HSP72_HUMAN (2-646): 0: 940: 85.47