Protein: TRM61
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A)

Gene: TRM61, TRMT61A
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q96FX7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006397 - mRNA processing
GO:0030488 - tRNA methylation
GO:0031515 - tRNA (m1A) methyltransferase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1391115

TRM6
tRNA

4

2

Small-scale

0.895

High

177399

ARHGB
Rho guanine nucleotide exchange factor 11

3

1

High-throughput

0.667

High

211387

RFOX2
RNA binding protein fox-1 homolog 2

3

0

High-throughput

0.638

High

1123078

FHL2
Four and a half LIM domains protein 2

3

0

High-throughput

0.638

High

1110531

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

3

0

High-throughput

0.634

High

1391111

ARHGC
Rho guanine nucleotide exchange factor 12

3

1

High-throughput

0.609

High

940459

TCL1A
T-cell leukemia/lymphoma protein 1A

2

0

High-throughput

0.580

High

227177

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

3

High-throughput

0.536

High

431215

LA
Lupus La protein

1

1

High-throughput

0.536

High

1109985

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.536

High

1391107

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.536

High

1259415

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

1291131

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1356430

TF3C2
General transcription factor 3C polypeptide 2

1

0

High-throughput

0.513

High

1368816

N42L2
NEDD4-binding protein 2-like 2

1

0

High-throughput

0.513

High

1370287

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1391102

TCAB1
Telomerase Cajal body protein 1

1

0

High-throughput

0.513

High

1391104

PLK3
Serine/threonine-protein kinase PLK3

1

0

High-throughput

0.513

High

1391108

SNRK
SNF-related serine/threonine-protein kinase

1

0

High-throughput

0.513

High

1391109

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.513

High

821500

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.489

High

1007199

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.489

High

1153012

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.489

High

1363670

TCPW
T-complex protein 1 subunit zeta-2

1

2

High-throughput

0.489

High

1391116

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.489

High

872623

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

998670

H31
Histone H3.1

1

2

High-throughput

0.479

High

1017108

H33
Histone H3.3

1

2

High-throughput

0.479

High

1391112

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

401290

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

589399

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696198

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768878

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1161598

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1329804

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1391105

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1391106

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1391114

XPO7
Exportin-7

1

0

High-throughput

0.458

High

191744

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.426

High

288729

NPM3
Nucleoplasmin-3

1

0

High-throughput

0.426

High

430231

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

810279

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

841070

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.426

High

1315239

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.426

High

1391100

CCNL2
Cyclin-L2

1

0

High-throughput

0.426

High

716159

PBLD
Phenazine biosynthesis-like domain-containing protein

3

0

High-throughput

0.347

High

884195

SRP09
Signal recognition particle 9 kDa protein

2

0

High-throughput

0.328

High

1391113

EVL
Ena/VASP-like protein

2

0

High-throughput

0.328

High

213226

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.279

Low

239169

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

331786

MTMR5
Myotubularin-related protein 5

1

0

High-throughput

0.279

Low

733737

GRK4
G protein-coupled receptor kinase 4

1

0

High-throughput

0.279

Low

1191931

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.279

Low

1200003

KLH26
Kelch-like protein 26

1

0

High-throughput

0.279

Low

1231949

MRCKG
Serine/threonine-protein kinase MRCK gamma

1

0

High-throughput

0.279

Low

1245320

WDR59
GATOR2 complex protein WDR59

1

0

High-throughput

0.279

Low

1246926

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.279

Low

1391101

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.279

Low

1391103

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.279

Low

1391117

EMIL1
EMILIN-1

1

0

High-throughput

0.279

Low

1255038

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1380327

MYDGF
Myeloid-derived growth factor

1

0

High-throughput

0.249

Low

640260

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.238

Low

47881

A0AUL9
ATG2A protein

1

0

High-throughput

0.232

Low

898759

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.232

Low

1278008

SZRD1
SUZ RNA-binding domain-containing

1

0

High-throughput

0.232

Low

1391110

USE1
Vesicle transport protein USE1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025