HitPredict

Interactor 1: HNRC1 (O60812)
Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1)
Gene: HNRNPCL1

Interactor 2: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 293 Hs			1 262
+	Hs
		71195 HNRC2_HUMAN (1-293): 3.5e-94: 281: 96.25		SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33
+	Hs
		241386 HNRC1_HUMAN (1-293): 1.3e-98: 293: 100.00		PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46
+	Hs
		432996 HNRPC_HUMAN (1-293): 1.35e-86: 262: 86.93		PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46
+	Hs
		432657 HNRPC_HUMAN (1-293): 1.35e-86: 262: 86.93		SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79
+	Hs
		432527 HNRPC_HUMAN (1-293): 1.35e-86: 262: 86.93		PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35
+	Hs
		1197556 RALYL_HUMAN (2-271): 1.26e-72: 226: 48.44		PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46
+	Hs
		1356521 RALY_HUMAN (2-280): 2.93e-66: 210: 40.33		PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46
+	Mm
		665756 RALY_MOUSE (2-280): 6.45e-73: 228: 38.76		PABP1_MOUSE (2-99): 6.34e-19: 87.9: 17.35
+	Hs
		952174 RALY_HUMAN (2-280): 2.93e-66: 210: 40.33		SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79
+	Hs
		516734 RALY_HUMAN (2-280): 2.93e-66: 210: 40.33		PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35
+	At
		955331 RS40_ARATH (14-272): 7.04e-36: 133: 18.01		CYP59_ARATH (6-259): 5.13e-31: 121: 19.29
+	Hs
		267035 SRS12_HUMAN (12-244): 2.13e-34: 127: 14.52		SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00
+	Hs
		952060 SRS12_HUMAN (12-244): 2.13e-34: 127: 14.52		SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79
+	Hs
		266958 TRA2B_HUMAN (25-151): 2.98e-21: 92.7: 23.08		SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00
+	Hs
		925150 TRA2B_HUMAN (25-151): 2.98e-21: 92.7: 23.08		PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46
+	Hs
		925003 TRA2B_HUMAN (25-151): 2.98e-21: 92.7: 23.08		SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79
+	Mm
		925159 TRA2B_MOUSE (25-151): 2.98e-21: 92.7: 23.08		SRSF3_MOUSE (1-95): 1.17e-25: 100: 35.79
+	Hs
		925007 TRA2B_HUMAN (25-151): 2.98e-21: 92.7: 23.08		SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65
+	At
		1093117 RSZ33_ARATH (8-109): 2.92e-18: 84.6: 21.57		SRC28_ARATH (8-187): 1.2e-24: 100: 35.00
+	Hs
		516451 TRA2B_HUMAN (25-151): 2.98e-21: 92.7: 23.08		PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35