Protein: IF4A2
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)

Gene: IF4A2, EIF4A2
Organism: Homo sapiens
Interactions: 173
UniProt ID: Q14240

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0003743 - translation initiation factor activity
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

953881

IF4A1
Eukaryotic initiation factor 4A-I

8

18

High-throughput

0.963

High

1047004

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

7

20

Small-scale

0.956

High

1124261

PDCD4
Programmed cell death protein 4

5

15

High-throughput

0.930

High

216087

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

3

20

High-throughput

0.839

High

1005671

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

3

20

Small-scale

0.839

High

1124308

TRI39
E3 ubiquitin-protein ligase TRIM39

2

6

High-throughput

0.811

High

141482

DDX3X
ATP-dependent RNA helicase DDX3X

2

16

High-throughput

0.754

High

1124249

IF4A2
Eukaryotic initiation factor 4A-II

1

17

High-throughput

0.698

High

1124300

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

High-throughput

0.691

High

187965

EIF3H
Eukaryotic translation initiation factor 3 subunit H

4

19

High-throughput

0.678

High

1124314

IBTK
Inhibitor of Bruton tyrosine kinase

2

9

High-throughput

0.675

High

445551

IF4E
Eukaryotic translation initiation factor 4E

3

5

High-throughput

0.667

High

855442

ATRX
Transcriptional regulator ATRX

1

20

High-throughput

0.665

High

295167

EIF3G
Eukaryotic translation initiation factor 3 subunit G

3

12

High-throughput

0.656

High

1121767

EIF3A
Eukaryotic translation initiation factor 3 subunit A

3

7

High-throughput

0.650

High

1124268

EIF3M
Eukaryotic translation initiation factor 3 subunit M

3

1

High-throughput

0.650

High

1124316

EIF3K
Eukaryotic translation initiation factor 3 subunit K

3

1

High-throughput

0.650

High

1124320

EIF3L
Eukaryotic translation initiation factor 3 subunit L

3

1

High-throughput

0.650

High

131426

EIF3F
Eukaryotic translation initiation factor 3 subunit F

3

11

High-throughput

0.640

High

1124317

IPO11
Importin-11

2

14

High-throughput

0.631

High

352435

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.618

High

623341

RO52
E3 ubiquitin-protein ligase TRIM21

1

6

High-throughput

0.618

High

684236

DDX6
Probable ATP-dependent RNA helicase DDX6

1

17

High-throughput

0.618

High

807416

IF4A3
Eukaryotic initiation factor 4A-III

1

16

High-throughput

0.618

High

1124258

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

7

High-throughput

0.618

High

1124281

RENT1
Regulator of nonsense transcripts 1

1

8

High-throughput

0.618

High

1124312

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.618

High

187714

EIF3D
Eukaryotic translation initiation factor 3 subunit D

2

2

High-throughput

0.601

High

550282

PABP1
Polyadenylate-binding protein 1

2

13

High-throughput

0.601

High

1124303

DDX24
ATP-dependent RNA helicase DDX24

1

17

High-throughput

0.590

High

1124307

ECT2
Protein ECT2

2

9

High-throughput

0.586

High

241666

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.584

High

939324

EIF3B
Eukaryotic translation initiation factor 3 subunit B

2

13

High-throughput

0.584

High

949355

EIF3E
Eukaryotic translation initiation factor 3 subunit E

2

2

High-throughput

0.584

High

1102828

EIF3I
Eukaryotic translation initiation factor 3 subunit I

2

14

High-throughput

0.584

High

1124290

SMG1
Serine/threonine-protein kinase SMG1

2

4

High-throughput

0.584

High

1124292

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

3

High-throughput

0.584

High

415564

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.582

High

1124278

PIHD2
PIH1 domain-containing protein 2

2

5

High-throughput

0.573

High

1124309

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.573

High

529788

TAU
Microtubule-associated protein tau

2

13

High-throughput

0.571

High

1124265

ZN620
Zinc finger protein 620

2

1

High-throughput

0.553

High

1124266

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.553

High

1124272

ANR35
Ankyrin repeat domain-containing protein 35

1

8

Small-scale

0.553

High

1124318

HECD1
E3 ubiquitin-protein ligase HECTD1

1

17

Small-scale

0.553

High

351485

FTCD
Formimidoyltransferase-cyclodeaminase

1

1

High-throughput

0.541

High

447011

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

884087

SRP09
Signal recognition particle 9 kDa protein

1

3

High-throughput

0.536

High

969856

RS16
Small ribosomal subunit protein uS9

1

6

High-throughput

0.536

High

973437

RS11
Small ribosomal subunit protein uS17

1

5

High-throughput

0.536

High

1124279

PSPC1
Paraspeckle component 1

1

20

High-throughput

0.536

High

1124291

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

1124297

RBM42
RNA-binding protein 42

1

18

High-throughput

0.536

High

1124321

DRG1
Developmentally-regulated GTP-binding protein 1

1

8

High-throughput

0.536

High

105926

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

227558

SPOP
Speckle-type POZ protein

2

3

High-throughput

0.533

High

1124269

MOT9
Monocarboxylate transporter 9

1

1

High-throughput

0.523

High

1124296

SH3G3
Endophilin-A3

2

6

High-throughput

0.521

High

168850

PLD2
Phospholipase D2

1

0

High-throughput

0.517

High

1124273

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.517

High

227875

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.515

High

243936

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

9

High-throughput

0.515

High

335835

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

1

High-throughput

0.515

High

447755

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.515

High

452258

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.515

High

973041

RS29
Small ribosomal subunit protein uS14

1

2

High-throughput

0.515

High

1034570

AK17A
A-kinase anchor protein 17A

1

3

High-throughput

0.515

High

1065925

VAC14
Protein VAC14 homolog

1

11

High-throughput

0.515

High

1102700

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.515

High

843559

HD
Huntingtin

1

2

High-throughput

0.515

High

927295

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

908827

NEK2
Serine/threonine-protein kinase Nek2

1

11

High-throughput

0.508

High

1124255

HSPB2
Heat shock protein beta-2

1

3

High-throughput

0.508

High

964279

SUMO2
Small ubiquitin-related modifier 2

1

8

High-throughput

0.501

High

943478

DSCR6
Protein ripply3

1

1

High-throughput

0.494

High

1124287

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.493

High

1124299

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

405458

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

799107

BRCA1
Breast cancer type 1 susceptibility protein

1

20

High-throughput

0.481

High

123696

MYO1C
Unconventional myosin-Ic

1

3

High-throughput

0.479

High

157363

CTRO
Citron Rho-interacting kinase

1

19

High-throughput

0.479

High

223030

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

247899

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

302521

RNF8
E3 ubiquitin-protein ligase RNF8

1

7

High-throughput

0.479

High

323372

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

330958

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

347703

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

404052

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

426023

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

2

High-throughput

0.479

High

485140

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

14

High-throughput

0.479

High

537147

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

563752

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.479

High

660627

IF4B
Eukaryotic translation initiation factor 4B

1

18

High-throughput

0.479

High

665434

EF1B
Elongation factor 1-beta

1

1

High-throughput

0.479

High

830725

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

845974

DCC
Netrin receptor DCC

1

3

Small-scale

0.479

High

867124

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.479

High

875659

PRC2A
Protein PRRC2A

1

19

High-throughput

0.479

High

888058

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

934604

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.479

High

947186

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

6

High-throughput

0.479

High

948826

CD81
CD81 antigen

1

5

High-throughput

0.479

High

986421

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

8

Small-scale

0.479

High

1029832

RUNX1
Runt-related transcription factor 1

1

4

High-throughput

0.479

High

1035611

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

1099884

TIF1B
Transcription intermediary factor 1-beta

1

19

High-throughput

0.479

High

1101952

PABP4
Polyadenylate-binding protein 4

1

10

High-throughput

0.479

High

1109550

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1124250

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

11

High-throughput

0.479

High

1124252

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

1124253

PCBP1
Poly(rC)-binding protein 1

1

13

Small-scale

0.479

High

1124254

SMAD2
Mothers against decapentaplegic homolog 2

1

13

High-throughput

0.479

High

1124259

CRY2
Cryptochrome-2

1

9

High-throughput

0.479

High

1124262

PRC2B
Protein PRRC2B

1

20

High-throughput

0.479

High

1124264

GGYF2
GRB10-interacting GYF protein 2

1

7

High-throughput

0.479

High

1124271

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

1124280

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

1124284

CHM4C
Charged multivesicular body protein 4c

1

9

High-throughput

0.479

High

1124285

OPTN
Optineurin

1

12

High-throughput

0.479

High

1124293

ATX2
Ataxin-2

1

8

High-throughput

0.479

High

1124295

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.479

High

1124298

SYTM
Threonine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1124302

TRI31
E3 ubiquitin-protein ligase TRIM31

1

19

High-throughput

0.479

High

1124306

TDRD3
Tudor domain-containing protein 3

1

3

High-throughput

0.479

High

1124310

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

1124311

ANLN
Anillin

1

5

High-throughput

0.479

High

1124313

RNF12
E3 ubiquitin-protein ligase RLIM

1

8

High-throughput

0.479

High

1124323

FBX7
F-box only protein 7

1

2

High-throughput

0.479

High

1124324

PRC2C
Protein PRRC2C

1

19

High-throughput

0.479

High

1124325

YTHD2
YTH domain-containing family protein 2

1

10

High-throughput

0.479

High

1124326

RBM8A
RNA-binding protein 8A

1

20

High-throughput

0.479

High

488312

PPBI
Intestinal-type alkaline phosphatase

1

2

High-throughput

0.470

High

1124286

DDT4L
DNA damage-inducible transcript 4-like protein

1

1

High-throughput

0.470

High

457438

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

1124277

DYH5
Dynein axonemal heavy chain 5

1

0

High-throughput

0.458

High

1124282

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1124288

CDCA5
Sororin

1

0

High-throughput

0.458

High

1124319

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

926178

ICLN
Methylosome subunit pICln

1

1

High-throughput

0.457

High

765505

BMI1
Polycomb complex protein BMI-1

1

12

High-throughput

0.445

High

1124263

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

1063244

GOGA2
Golgin subfamily A member 2

1

9

High-throughput

0.439

High

136895

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

4

High-throughput

0.437

High

324859

HEXI1
Protein HEXIM1

1

6

High-throughput

0.437

High

378864

CD4
T-cell surface glycoprotein CD4

1

2

Small-scale

0.437

High

588682

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.437

High

695440

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

768175

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

837613

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

5

High-throughput

0.437

High

879082

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

12

High-throughput

0.437

High

1109583

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.437

High

1124251

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.437

High

1124256

CRY1
Cryptochrome-1

1

9

High-throughput

0.437

High

1124260

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

1124270

PLD3
5'-3' exonuclease PLD3

1

2

High-throughput

0.437

High

1124274

PLD5
Inactive phospholipase D5

1

2

High-throughput

0.437

High

1124276

TIP
T-cell immunomodulatory protein

1

3

High-throughput

0.437

High

1124283

PLD4
5'-3' exonuclease PLD4

1

2

High-throughput

0.437

High

1124289

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

1124301

ACE2
Angiotensin-converting enzyme 2

1

5

Small-scale

0.437

High

1124304

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.437

High

1124315

GBG12

1

1

High-throughput

0.437

High

404787

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1119122

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.407

High

1124267

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.299

High

1124294

MDFI
MyoD family inhibitor

1

0

High-throughput

0.299

High

1124322

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.299

High

1124257

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.279

Low

261805

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

1124275

MCPH1
Microcephalin

1

0

Small-scale

0.251

Low

1083467

MN1
Transcriptional activator MN1

1

0

Small-scale

0.249

Low

1124305

Q9H376
PRO0720

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025