HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: K22O (Q01546)
Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)
Gene: KRT76

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 638
+	Hs
		240491 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59
+	Hs
		240542 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		K2C7_HUMAN (66-510): 2.57e-144: 429: 58.20
+	Hs
		240461 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		K2C1_HUMAN (148-514): 1.73e-111: 350: 68.94
+	Hs
		437327 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59
+	Hs
		334967 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59
+	Hs
		240389 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		K2C75_HUMAN (1-584): 6.54e-92: 296: 54.76
+	Hs
		240626 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		K2C5_HUMAN (1-499): 5.54e-86: 282: 62.85
+	Hs
		241970 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		K2C79_HUMAN (73-513): 1.65e-85: 279: 63.88
+	Hs
		240460 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		K2C6B_HUMAN (2-515): 4.79e-82: 271: 62.02
+	Hs
		407521 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		K2C1_HUMAN (148-514): 1.73e-111: 350: 68.94
+	Hs
		334960 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		K2C1_HUMAN (148-514): 1.73e-111: 350: 68.94
+	Hs
		566446 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		K2C5_HUMAN (1-499): 5.54e-86: 282: 62.85
+	Hs
		407338 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		K2C6B_HUMAN (2-515): 4.79e-82: 271: 62.02
+	Hs
		551590 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		K2C3_HUMAN (1-500): 4.36e-72: 246: 77.99
+	Hs
		335127 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		K2C72_HUMAN (268-616): 3.25e-09: 61.9: 14.66