HitPredict

Interactor 1: H2B1K (O60814)
Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)
Gene: H2BC12

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 217
+	Hs
		924623 H2B2F_HUMAN (1-126): 2.19e-54: 168: 97.62		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924820 H2B1M_HUMAN (1-126): 4.46e-54: 167: 96.03		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		883010 H2BFS_HUMAN (1-126): 9.81e-54: 166: 98.41		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		918279 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924770 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924819 H2B1N_HUMAN (1-126): 2.97e-53: 165: 98.41		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		886077 H2B1D_HUMAN (1-126): 3.17e-53: 164: 98.41		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924821 H2B1L_HUMAN (1-126): 2.18e-52: 163: 97.62		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411752 H2B2F_HUMAN (1-126): 2.19e-54: 168: 97.62		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411835 H2B1M_HUMAN (1-126): 4.46e-54: 167: 96.03		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411664 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411813 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411834 H2B1N_HUMAN (1-126): 2.97e-53: 165: 98.41		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411656 H2B1D_HUMAN (1-126): 3.17e-53: 164: 98.41		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411836 H2B1L_HUMAN (1-126): 2.18e-52: 163: 97.62		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		557845 U3KQK0_HUMAN (1-126): 3.64e-55: 171: 98.41		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		557647 H2B1D_HUMAN (1-126): 3.17e-53: 164: 98.41		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		557738 H2B3B_HUMAN (1-126): 8.48e-52: 161: 94.44		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14