Protein: NOP4
Nucleolar protein 4 (Nucleolar protein NOP77)

Gene: NOP4
Organism: Saccharomyces cerevisiae S288C
Interactions: 172
UniProt ID: P37838

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0042273 - ribosomal large subunit biogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

791119

NOP12
Nucleolar protein 12

6

19

Small-scale

0.951

High

791086

NOP15
Ribosome biogenesis protein 15

4

19

High-throughput

0.892

High

791084

NOP13
Nucleolar protein 13

4

19

Small-scale

0.891

High

791045

NOP4
Nucleolar protein 4

3

18

Small-scale

0.880

High

692556

NSR1
Nuclear localization sequence-binding protein

2

20

High-throughput

0.767

High

791058

NOC2
Nucleolar complex protein 2

8

1

Small-scale

0.753

High

791100

HAS1
ATP-dependent RNA helicase HAS1

9

14

Small-scale

0.753

High

791047

MAK5
ATP-dependent RNA helicase MAK5

7

16

Small-scale

0.751

High

791052

CIC1
Proteasome-interacting protein CIC1

8

4

Small-scale

0.751

High

791139

RRP12
Ribosomal RNA-processing protein 12

7

1

Small-scale

0.749

High

791133

MAK21
Ribosome biogenesis protein MAK21

7

3

High-throughput

0.748

High

791097

NOG1
Nucleolar GTP-binding protein 1

8

5

Small-scale

0.747

High

791079

PESC
Pescadillo homolog

7

1

Small-scale

0.742

High

403473

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

18

Small-scale

0.737

High

746615

DRS1
ATP-dependent RNA helicase DRS1

6

15

Small-scale

0.737

High

780250

EBP2
rRNA-processing protein EBP2

6

2

Small-scale

0.736

High

791061

NUG1
Nuclear GTP-binding protein NUG1

6

3

Small-scale

0.731

High

791067

NOP2
25S rRNA

6

3

Small-scale

0.729

High

791110

RRP5
rRNA biogenesis protein RRP5

6

6

Small-scale

0.726

High

791053

SSF1
Ribosome biogenesis protein SSF1

6

2

Small-scale

0.722

High

791136

DBP10
ATP-dependent RNA helicase DBP10

5

14

Small-scale

0.722

High

782313

RPF2
Ribosome biogenesis protein RPF2

5

3

Small-scale

0.706

High

410074

RL25
Large ribosomal subunit protein uL23

2

5

High-throughput

0.705

High

682256

SPB4
ATP-dependent rRNA helicase SPB4

5

12

Small-scale

0.705

High

791062

NSA2
Ribosome biogenesis protein NSA2

4

1

Small-scale

0.692

High

517997

SSBP1
Single-stranded nucleic acid-binding protein

1

17

High-throughput

0.691

High

585912

CSK21
Casein kinase II subunit alpha

1

11

High-throughput

0.691

High

721858

XPO1
Exportin-1

1

6

High-throughput

0.691

High

735257

KNS1
Dual specificity protein kinase KNS1

1

11

High-throughput

0.691

High

791134

RL7B
Large ribosomal subunit protein uL30B

1

7

High-throughput

0.691

High

791066

RLP7
Ribosome biogenesis protein RLP7

4

7

High-throughput

0.691

High

791068

UTP10
U3 small nucleolar RNA-associated protein 10

4

1

High-throughput

0.691

High

791108

ERB1
Ribosome biogenesis protein ERB1

4

8

High-throughput

0.691

High

791120

BRX1
Ribosome biogenesis protein BRX1

4

10

Small-scale

0.691

High

758200

URB1
Nucleolar pre-ribosomal-associated protein 1

4

1

Small-scale

0.678

High

791075

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

4

Small-scale

0.672

High

780669

RRP14
Ribosomal RNA-processing protein 14

4

0

Small-scale

0.667

High

751382

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

3

High-throughput

0.667

High

523671

HSP71
Heat shock protein SSA1

4

3

High-throughput

0.666

High

763559

UTP20
U3 small nucleolar RNA-associated protein 20

3

1

High-throughput

0.662

High

791085

NAT10
RNA cytidine acetyltransferase

3

1

High-throughput

0.662

High

791114

DBP9
ATP-dependent RNA helicase DBP9

3

9

High-throughput

0.662

High

791130

YTM1
Ribosome biogenesis protein YTM1

3

15

High-throughput

0.662

High

791137

NOP56
Nucleolar protein 56

3

3

High-throughput

0.662

High

791105

PUF6
Pumilio homology domain family member 6

3

8

Small-scale

0.657

High

791060

NOP16
Nucleolar protein 16

4

0

Small-scale

0.651

High

791069

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

0

High-throughput

0.642

High

791129

MDN1
Midasin

2

1

High-throughput

0.621

High

791077

CGR1
rRNA-processing protein CGR1

3

0

Small-scale

0.619

High

791125

TMA16
Translation machinery-associated protein 16

3

0

Small-scale

0.619

High

791091

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

8

High-throughput

0.618

High

435024

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.618

High

700232

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

1

High-throughput

0.588

High

644910

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.586

High

763056

RRP1
Ribosomal RNA-processing protein 1

2

4

Small-scale

0.584

High

791065

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

791082

NOG2
Nucleolar GTP-binding protein 2

2

3

High-throughput

0.584

High

791131

NOP53
Ribosome biogenesis protein NOP53

2

3

High-throughput

0.584

High

791132

RRP6
Exosome complex exonuclease RRP6

2

1

High-throughput

0.584

High

791138

NOP58
Nucleolar protein 58

2

3

High-throughput

0.584

High

791049

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

419408

H2A1
Histone H2A.1

1

10

High-throughput

0.536

High

531696

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.536

High

645388

XRN1
5'-3' exoribonuclease 1

1

5

High-throughput

0.536

High

684691

RL5
Large ribosomal subunit protein uL18

1

4

High-throughput

0.536

High

689006

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.536

High

791081

BRE5
UBP3-associated protein BRE5

1

11

High-throughput

0.536

High

791092

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

558680

CAF20
Cap-associated protein CAF20

2

1

High-throughput

0.533

High

433008

RL6B
Large ribosomal subunit protein eL6B

1

3

High-throughput

0.489

High

569978

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.489

High

712544

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.489

High

791048

ARPC1
Actin-related protein 2/3 complex subunit 1

1

12

High-throughput

0.489

High

791051

OSH3
Oxysterol-binding protein homolog 3

1

1

High-throughput

0.489

High

791090

AP1M1
AP-1 complex subunit mu-1-I

1

3

High-throughput

0.489

High

791115

MAG2
E3 ubiquitin-protein ligase MAG2

1

1

High-throughput

0.489

High

149712

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

433590

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

435912

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

436384

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

9

High-throughput

0.479

High

441858

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

512391

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.479

High

513671

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.479

High

534101

MAK16
Protein MAK16

1

1

High-throughput

0.479

High

633153

MAK11
Protein MAK11

1

15

High-throughput

0.479

High

637206

PWP1
Periodic tryptophan protein 1

1

13

High-throughput

0.479

High

670589

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

674567

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

677188

SPB1
27S pre-rRNA

1

5

High-throughput

0.479

High

677358

KRR1
KRR1 small subunit processome component

1

4

High-throughput

0.479

High

689401

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

706847

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

709707

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

721603

RENT1
ATP-dependent helicase NAM7

1

12

Small-scale

0.479

High

745707

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

4

High-throughput

0.479

High

750065

MRT4
Ribosome assembly factor MRT4

1

2

High-throughput

0.479

High

776554

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

780009

EAP1
Protein EAP1

1

1

High-throughput

0.479

High

791046

GBLP
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.479

High

791050

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

791056

RIX1
Pre-rRNA-processing protein RIX1

1

1

Small-scale

0.479

High

791059

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

15

Small-scale

0.479

High

791064

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

791074

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.479

High

791078

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.479

High

791080

YG5X
Putative methyltransferase YGR283C

1

1

High-throughput

0.479

High

791083

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

High-throughput

0.479

High

791088

ORC1
Origin recognition complex subunit 1

1

6

High-throughput

0.479

High

791096

XRN2
5'-3' exoribonuclease 2

1

5

High-throughput

0.479

High

791099

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.479

High

791103

DHR1
Probable ATP-dependent RNA helicase DHR1

1

7

High-throughput

0.479

High

791106

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.479

High

791109

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.479

High

791111

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

791112

FKBP4
FK506-binding protein 4

1

1

High-throughput

0.479

High

791113

JIP5
WD repeat-containing protein JIP5

1

5

High-throughput

0.479

High

791116

NOC4
Nucleolar complex protein 4

1

3

High-throughput

0.479

High

791118

RLP24
Ribosome biogenesis protein RLP24

1

2

High-throughput

0.479

High

791121

REXO4
RNA exonuclease 4

1

5

High-throughput

0.479

High

791123

SGO1
Shugoshin

1

1

High-throughput

0.479

High

791124

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.479

High

791127

RRS1
Regulator of ribosome biosynthesis

1

2

High-throughput

0.479

High

791128

NIP7
60S ribosome subunit biogenesis protein NIP7

1

1

High-throughput

0.479

High

448304

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

672877

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

677918

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

734939

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

791055

RPF1
Ribosome production factor 1

1

0

High-throughput

0.458

High

791070

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

791071

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.458

High

791076

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

791087

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

791098

ESP1
Separin

1

0

High-throughput

0.458

High

791102

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

791122

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

392583

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

427231

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.445

High

509505

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

19

High-throughput

0.445

High

544546

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

791063

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

791073

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.445

High

791089

SEN1
Helicase SEN1

1

13

Small-scale

0.445

High

383652

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

455013

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

502993

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504168

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

512958

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

513982

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.437

High

514593

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

554911

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.437

High

596812

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

2

High-throughput

0.437

High

747313

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

748351

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

753317

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

778276

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

791057

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

791072

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

791093

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

791104

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.437

High

791107

POB3
FACT complex subunit POB3

1

2

High-throughput

0.437

High

791126

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

653851

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

791094

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.417

High

791101

BUL2
Ubiquitin ligase-binding protein BUL2

2

0

Small-scale

0.318

High

503780

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

752154

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

791054

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

791095

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

791117

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

751260

RIB7
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

1

0

High-throughput

0.232

Low

791135

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025