HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FBXW9 (Q5XUX1)
F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9)
Gene: FBXW9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F-box-like~ubiquitin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 458
+	Hs
		242505 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		FBXW7_HUMAN (52-410): 8.14e-78: 257: 16.62
+	Hs
		243097 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		NLE1_HUMAN (11-291): 8.43e-38: 145: 14.37
+	Hs
		242544 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		SNR40_HUMAN (8-248): 3.72e-23: 102: 11.33
+	Hs
		1380291 ARI1_HUMAN (163-464): 4.18e-73: 242: 19.67		FBXW7_HUMAN (52-410): 8.14e-78: 257: 16.62
+	Hs
		240994 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		LIS1_HUMAN (385-458): 9.15e-17: 83.8: 20.51
+	Hs
		243327 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		FBW1A_HUMAN (59-222): 7.01e-15: 78.8: 12.64
+	Hs
		243252 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		FBW1B_HUMAN (59-222): 1.72e-14: 77.6: 13.22
+	Hs
		241283 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		WDR5_HUMAN (381-458): 9.45e-15: 76.8: 23.17
+	Hs
		1310775 CUL9_HUMAN (30-463): 4.64e-78: 267: 18.81		SNR40_HUMAN (8-248): 3.72e-23: 102: 11.33
+	Sc
		509552 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		MET30_YEAST (88-332): 5.35e-29: 121: 13.38
+	Hs
		1490651 ARI1_HUMAN (163-464): 4.18e-73: 242: 19.67		FBW1A_HUMAN (59-222): 7.01e-15: 78.8: 12.64
+	Hs
		1461023 ARI1_HUMAN (163-464): 4.18e-73: 242: 19.67		FBW1B_HUMAN (59-222): 1.72e-14: 77.6: 13.22
+	Sc
		509617 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		MDV1_YEAST (215-457): 2.99e-22: 101: 15.93
+	Sc
		460702 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		CDC4_YEAST (158-325): 1.97e-12: 71.4: 20.11
+	At
		199339 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		O22826_ARATH (6-290): 5.02e-34: 132: 12.70