HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FAF2 (Q96CS3)
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Gene: FAF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0031625 - ubiquitin protein ligase binding GO:0036503 - ERAD pathway GO:0043130 - ubiquitin binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 445
+	Hs
		240341 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		UBXN7_HUMAN (1-441): 1.1e-116: 352: 16.34
+	Hs
		243293 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		FAF1_HUMAN (112-440): 5.65e-83: 269: 24.79
+	Hs
		507306 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		FAF2_HUMAN (1-445): 1.33e-143: 419: 100.00
+	Hs
		320614 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		UBXN7_HUMAN (1-441): 1.1e-116: 352: 16.34
+	Hs
		241457 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		UBXN1_HUMAN (295-439): 7.97e-19: 88.4: 16.36
+	Hs
		507428 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		FAF1_HUMAN (112-440): 5.65e-83: 269: 24.79
+	Sc
		509736 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		UBX5_YEAST (14-445): 5.59e-80: 257: 11.89
+	Sc
		509710 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		UBX2_YEAST (9-430): 9.08e-66: 222: 16.38